On testing the bioequivalence of several treatments using the measure of distance

Hubert J. Chen, Miin Jye Wen, Andrew Minglong Wang

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


A studentized range test is proposed to test the hypothesis of bioequivalence of normal means in terms of a standardized distance among means. A least favourable configuration (LFC) of means to guarantee the maximum level at a null hypothesis and an LFC of means to guarantee the minimum power at an alternative hypothesis are obtained. This level and power of the test are fully independent of the unknown means and variances. For a given level, the critical value of the test under a null hypothesis can be determined. Furthermore, if the power under an alternative is also required at a given level, then both the critical value and the required sample size for an experiment can be simultaneously determined. In situations where the common population variance is unknown and the bioequivalence is the actual distance between means without standardization, a two-stage sampling procedure can be employed to find these solutions.

Original languageEnglish
Pages (from-to)513-530
Number of pages18
Issue number5
Publication statusPublished - 2009 Oct

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Statistics, Probability and Uncertainty


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