On the interaction of dipalmitoyl phosphatidylcholine with normal long-chain alcohols in a mixed monolayer: A thermodynamic study

Kai Bin Chen, Chien Hsiang Chang, Yu Min Yang, Jer Ru Maa

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

This study investigated the mixed monolayer behavior of dipalmitoyl phosphatidylcholine (DPPC) with normal long-chain alcohols at the air/water interface. Surface pressure-area isotherms of mixed DPPC/C18OH and DPPC/C20OH monolayers at 37°C were obtained and compared with previous results for the mixed DPPC/C16OH system. The negative deviations from additivity of the areas and the variation of the collapse pressure with composition imply that DPPC and long-chain alcohols were miscible and formed non-ideal monolayers at the interface. At lower surface pressures, it seems that the attractive intermolecular force was dominant in molecular packing in the mixed monolayers. At higher surface pressures, the data suggest that the molecular packing in mixed DPPC/C16OH monolayers may be favored by the packing efficiency or geometric accommodation. Furthermore, negative values of excess free energy of mixing were obtained and became significant as the hydrocarbon chain length of alcohols increased, which indicates there were attractive interactions between DPPC and long-chain alcohols. In each free energy of mixing-composition curve, there was only one minimum and thus a phase separation did not exist for mixed DPPC/long-chain alcohol monolayers. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)199-208
Number of pages10
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Volume170
Issue number2-3
DOIs
Publication statusPublished - 2000 Sep

All Science Journal Classification (ASJC) codes

  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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