On the stability of liposomes and catansomes in aqueous alcohol solutions

Yu Min Yang, Kuo Chang Wu, Zheng Lin Huang, Chien-Hsiang Chang

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


In this work, a systematic study of effects of three cosolvents (methanol, ethanol, and 1-propanol) on the stability of liposomes formed from soybean phosphatidylcholine (PL-90) by a semispontaneous process was carried out. The experimental results revealed that significant enhancement of PL-90 liposome stability could be achieved by cosol vent addition with suitable amounts. A similar phenomenon was also observed for catansomes formed from ion-pair amphiphiles (IPAs) as demonstrated by decyltrimethylammonium dodecyl sulfate (DeTMA-DS) with a comparatively high concentration of 5 mM. In general, with continued increase in the cosolvent concentration, the stability of liposomes and catansomes first increased, reached a maximum, and then decreased. Furthermore, it was realized that the cosolvent effects on the liposome stability were very similar to those on the catansome stability, which might be also explained by the mechanism proposed on the basis of the viewpoint of a mixed solvent dielectric constant.

Original languageEnglish
Pages (from-to)1695-1700
Number of pages6
Issue number5
Publication statusPublished - 2008 Mar 4

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry


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