On the stability of liposomes and catansomes in aqueous alcohol solutions

Yu Min Yang, Kuo Chang Wu, Zheng L. Huang, Chien-Hsiang Chang

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

In this work, a systematic study of effects of three cosolvents (methanol, ethanol, and 1-propanol) on the stability of liposomes formed from soybean phosphatidylcholine (PL-90) by a semispontaneous process was carried out. The experimental results revealed that significant enhancement of PL-90 liposome stability could be achieved by cosol vent addition with suitable amounts. A similar phenomenon was also observed for catansomes formed from ion-pair amphiphiles (IPAs) as demonstrated by decyltrimethylammonium dodecyl sulfate (DeTMA-DS) with a comparatively high concentration of 5 mM. In general, with continued increase in the cosolvent concentration, the stability of liposomes and catansomes first increased, reached a maximum, and then decreased. Furthermore, it was realized that the cosolvent effects on the liposome stability were very similar to those on the catansome stability, which might be also explained by the mechanism proposed on the basis of the viewpoint of a mixed solvent dielectric constant.

Original languageEnglish
Pages (from-to)1695-1700
Number of pages6
JournalLangmuir
Volume24
Issue number5
DOIs
Publication statusPublished - 2008 Mar 4

Fingerprint

Liposomes
alcohols
Alcohols
1-Propanol
soybeans
Amphiphiles
Vents
vents
Propanol
Phosphatidylcholines
Methanol
sulfates
Ethanol
ethyl alcohol
Permittivity
methyl alcohol
Ions
permittivity
augmentation
ions

All Science Journal Classification (ASJC) codes

  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry

Cite this

Yang, Yu Min ; Wu, Kuo Chang ; Huang, Zheng L. ; Chang, Chien-Hsiang. / On the stability of liposomes and catansomes in aqueous alcohol solutions. In: Langmuir. 2008 ; Vol. 24, No. 5. pp. 1695-1700.
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On the stability of liposomes and catansomes in aqueous alcohol solutions. / Yang, Yu Min; Wu, Kuo Chang; Huang, Zheng L.; Chang, Chien-Hsiang.

In: Langmuir, Vol. 24, No. 5, 04.03.2008, p. 1695-1700.

Research output: Contribution to journalArticle

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