One-step hot microembossing for fabrication of paper-based microfluidic chips in 10 seconds

Yi Je Juang, Yu Wang, Shu Kai Hsu

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


In recent years, microfluidic paper-based analytical devices (µPADs) have been developed because they are simple, inexpensive and power-free for low-cost chemical, biological and environmental detection. Moreover, paper is lightweight; easy to stack, store and transport; biodegradable; biocompatible; good for colorimetric tests; flammable for easy disposal of used paper-based diagnostic devices by incineration; and can be chemically modified. Different methods have been demonstrated to fabricate µPADs such as solid wax printing, craft cutting, photolithography, etc. In this study, one-step hot microembossing was proposed and demonstrated to fabricate µPADs. The processing parameters like embossing temperature, pressure and time were systematically investigated. It was found that, at 55 C embossing temperature, the embossing pressure ranging from 10 to 14 MPa could be applied and the embossing time was only 5 s. This led to the overall processing time for fabrication of µPADs within 10 s. Glucose detection was conducted using the µPADs as fabricated, and a linear relationship was obtained between 5 and 50 mM.

Original languageEnglish
Article number2493
Pages (from-to)1-10
Number of pages10
Issue number11
Publication statusPublished - 2020 Nov

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Polymers and Plastics


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