Opioid users with comorbid hepatitis C spent more time in agonist therapy: A 6-year observational study in Taiwan

Horng Maw Chen, Tsung Hsueh Lu, Kun Chia Chang, Kuan Ying Lee, Ching Ming Cheng

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background Hepatitis C virus (HCV) infection is highly prevalent among opioid agonist therapy (OAT) patients, but little is known about long-term OAT use among this population. Methods Subjects diagnosed as opioid dependence were recruited from Mar. 2006 to Jul. 2008 in a psychiatry center in southern Taiwan with the OAT censored in 2012, and their socio-demographics, drug use characteristics, and markers of blood-borne infection were assessed at entry. Correlates with HCV infection and OAT retention were analyzed by multivariate logistic regression. Retention (OAT utilization) was defined as the in-treatment period of OAT during the 6-year observation period. Results A total of 983 patients (88.3% men) were included. The prevalences of HCV and HIV infection were 91.4% and 17.9%, respectively. The mean duration of OAT during the study period was 2.3±0.8years. Significant correlates with HCV infection were retention of at least three years in OAT (AOR: 4.24, 95%CI: 1.49–12.03), ever sharing injection equipment (AOR: 227.04, 95%CI: 57.22–900.87), not living with family (AOR: 5.54, 95%CI: 1.45–21.16), lower educational attainment (AOR: 2.10, 95%CI: 1.15–3.82) and previous drug offense (AOR: 6.35, 95%CI: 1.69–23.83). Significant correlates with retention were HCV infection (AOR: 2.53, 95%CI: 1.30–4.93) and divorced or separation in marriage (AOR: 0.65, 95%CI: 0.44–0.96). Conclusions This six-year observational study revealed a better retention in OAT if opioid-dependent individuals had comorbid hepatitis C. This provided opportunities for OAT patients with HCV infection to obtain medical treatment while staying in an OAT program. Further research could explore the possibility of eradicating comorbid HCV infection among these long-term treatment cases.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalAddictive Behaviors
Volume72
DOIs
Publication statusPublished - 2017 Sep 1

Fingerprint

Hepatitis C
Taiwan
Opioid Analgesics
Observational Studies
Viruses
Virus Diseases
Hepacivirus
Therapeutics
Divorce
Pharmaceutical Preparations
Marriage
Logistics
HIV Infections
Psychiatry
Blood
Logistic Models
Observation

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Toxicology
  • Psychiatry and Mental health

Cite this

Chen, Horng Maw ; Lu, Tsung Hsueh ; Chang, Kun Chia ; Lee, Kuan Ying ; Cheng, Ching Ming. / Opioid users with comorbid hepatitis C spent more time in agonist therapy : A 6-year observational study in Taiwan. In: Addictive Behaviors. 2017 ; Vol. 72. pp. 133-137.
@article{9639e47cc09346b8bdf0735eb34b7a57,
title = "Opioid users with comorbid hepatitis C spent more time in agonist therapy: A 6-year observational study in Taiwan",
abstract = "Background Hepatitis C virus (HCV) infection is highly prevalent among opioid agonist therapy (OAT) patients, but little is known about long-term OAT use among this population. Methods Subjects diagnosed as opioid dependence were recruited from Mar. 2006 to Jul. 2008 in a psychiatry center in southern Taiwan with the OAT censored in 2012, and their socio-demographics, drug use characteristics, and markers of blood-borne infection were assessed at entry. Correlates with HCV infection and OAT retention were analyzed by multivariate logistic regression. Retention (OAT utilization) was defined as the in-treatment period of OAT during the 6-year observation period. Results A total of 983 patients (88.3{\%} men) were included. The prevalences of HCV and HIV infection were 91.4{\%} and 17.9{\%}, respectively. The mean duration of OAT during the study period was 2.3±0.8years. Significant correlates with HCV infection were retention of at least three years in OAT (AOR: 4.24, 95{\%}CI: 1.49–12.03), ever sharing injection equipment (AOR: 227.04, 95{\%}CI: 57.22–900.87), not living with family (AOR: 5.54, 95{\%}CI: 1.45–21.16), lower educational attainment (AOR: 2.10, 95{\%}CI: 1.15–3.82) and previous drug offense (AOR: 6.35, 95{\%}CI: 1.69–23.83). Significant correlates with retention were HCV infection (AOR: 2.53, 95{\%}CI: 1.30–4.93) and divorced or separation in marriage (AOR: 0.65, 95{\%}CI: 0.44–0.96). Conclusions This six-year observational study revealed a better retention in OAT if opioid-dependent individuals had comorbid hepatitis C. This provided opportunities for OAT patients with HCV infection to obtain medical treatment while staying in an OAT program. Further research could explore the possibility of eradicating comorbid HCV infection among these long-term treatment cases.",
author = "Chen, {Horng Maw} and Lu, {Tsung Hsueh} and Chang, {Kun Chia} and Lee, {Kuan Ying} and Cheng, {Ching Ming}",
year = "2017",
month = "9",
day = "1",
doi = "10.1016/j.addbeh.2017.03.028",
language = "English",
volume = "72",
pages = "133--137",
journal = "Addictive Behaviors",
issn = "0306-4603",
publisher = "Elsevier Limited",

}

Opioid users with comorbid hepatitis C spent more time in agonist therapy : A 6-year observational study in Taiwan. / Chen, Horng Maw; Lu, Tsung Hsueh; Chang, Kun Chia; Lee, Kuan Ying; Cheng, Ching Ming.

In: Addictive Behaviors, Vol. 72, 01.09.2017, p. 133-137.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Opioid users with comorbid hepatitis C spent more time in agonist therapy

T2 - A 6-year observational study in Taiwan

AU - Chen, Horng Maw

AU - Lu, Tsung Hsueh

AU - Chang, Kun Chia

AU - Lee, Kuan Ying

AU - Cheng, Ching Ming

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Background Hepatitis C virus (HCV) infection is highly prevalent among opioid agonist therapy (OAT) patients, but little is known about long-term OAT use among this population. Methods Subjects diagnosed as opioid dependence were recruited from Mar. 2006 to Jul. 2008 in a psychiatry center in southern Taiwan with the OAT censored in 2012, and their socio-demographics, drug use characteristics, and markers of blood-borne infection were assessed at entry. Correlates with HCV infection and OAT retention were analyzed by multivariate logistic regression. Retention (OAT utilization) was defined as the in-treatment period of OAT during the 6-year observation period. Results A total of 983 patients (88.3% men) were included. The prevalences of HCV and HIV infection were 91.4% and 17.9%, respectively. The mean duration of OAT during the study period was 2.3±0.8years. Significant correlates with HCV infection were retention of at least three years in OAT (AOR: 4.24, 95%CI: 1.49–12.03), ever sharing injection equipment (AOR: 227.04, 95%CI: 57.22–900.87), not living with family (AOR: 5.54, 95%CI: 1.45–21.16), lower educational attainment (AOR: 2.10, 95%CI: 1.15–3.82) and previous drug offense (AOR: 6.35, 95%CI: 1.69–23.83). Significant correlates with retention were HCV infection (AOR: 2.53, 95%CI: 1.30–4.93) and divorced or separation in marriage (AOR: 0.65, 95%CI: 0.44–0.96). Conclusions This six-year observational study revealed a better retention in OAT if opioid-dependent individuals had comorbid hepatitis C. This provided opportunities for OAT patients with HCV infection to obtain medical treatment while staying in an OAT program. Further research could explore the possibility of eradicating comorbid HCV infection among these long-term treatment cases.

AB - Background Hepatitis C virus (HCV) infection is highly prevalent among opioid agonist therapy (OAT) patients, but little is known about long-term OAT use among this population. Methods Subjects diagnosed as opioid dependence were recruited from Mar. 2006 to Jul. 2008 in a psychiatry center in southern Taiwan with the OAT censored in 2012, and their socio-demographics, drug use characteristics, and markers of blood-borne infection were assessed at entry. Correlates with HCV infection and OAT retention were analyzed by multivariate logistic regression. Retention (OAT utilization) was defined as the in-treatment period of OAT during the 6-year observation period. Results A total of 983 patients (88.3% men) were included. The prevalences of HCV and HIV infection were 91.4% and 17.9%, respectively. The mean duration of OAT during the study period was 2.3±0.8years. Significant correlates with HCV infection were retention of at least three years in OAT (AOR: 4.24, 95%CI: 1.49–12.03), ever sharing injection equipment (AOR: 227.04, 95%CI: 57.22–900.87), not living with family (AOR: 5.54, 95%CI: 1.45–21.16), lower educational attainment (AOR: 2.10, 95%CI: 1.15–3.82) and previous drug offense (AOR: 6.35, 95%CI: 1.69–23.83). Significant correlates with retention were HCV infection (AOR: 2.53, 95%CI: 1.30–4.93) and divorced or separation in marriage (AOR: 0.65, 95%CI: 0.44–0.96). Conclusions This six-year observational study revealed a better retention in OAT if opioid-dependent individuals had comorbid hepatitis C. This provided opportunities for OAT patients with HCV infection to obtain medical treatment while staying in an OAT program. Further research could explore the possibility of eradicating comorbid HCV infection among these long-term treatment cases.

UR - http://www.scopus.com/inward/record.url?scp=85017155951&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017155951&partnerID=8YFLogxK

U2 - 10.1016/j.addbeh.2017.03.028

DO - 10.1016/j.addbeh.2017.03.028

M3 - Article

C2 - 28395249

AN - SCOPUS:85017155951

VL - 72

SP - 133

EP - 137

JO - Addictive Behaviors

JF - Addictive Behaviors

SN - 0306-4603

ER -