Optically-induced dielectrophoresis using polymer materials for biomedical applications

Gwo Bin Vincent Lee, Yen Heng Lin, Wang Ying Lin, Wei Wang, Tzung Fang Guo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

This paper briefly demonstrates three kinds of microfluidic modules by using a polymer-based optically-induced dielectrophoresis (ODEP) platform. Polymer materials with excellent optoelectronic efficiency can be mass-produced at room temperature using a spin-coating process. This approach can easily facilitate the mass-fabrication process of the ODEP chip. The first function presented in this platform is a cell lysis device. Experimental result shows that it can selectively lyse a single cell within a group of cells, which is a function cannot be performed using traditional tools. Besides, the function that selectively disrupts the cell membrane without damaging the nucleus can also be achieved. Second, an optically-induced flow cytometry is reported, which enables one to continuously count and to sort microparticles based on the ODEP forces. No complicated fabrication process is needed to achieve the cytometry function. The particles can be focused by the ODEP forces and detect through a pair of optical fibers embedded into fiber channels in real time. Third, a new method which can quickly separate micro-particles with different sizes using this platform is demonstrated. Three operation modes including light wavelength, light intensity and light width are successfully used to separate the microparticles with a high-throughput. The developed polymer-based ODEP platform can be widely applied in biomedical research.

Original languageEnglish
Title of host publicationTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
Pages2135-2138
Number of pages4
DOIs
Publication statusPublished - 2009 Dec 11
EventTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems - Denver, CO, United States
Duration: 2009 Jun 212009 Jun 25

Publication series

NameTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems

Other

OtherTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
CountryUnited States
CityDenver, CO
Period09-06-2109-06-25

All Science Journal Classification (ASJC) codes

  • Hardware and Architecture
  • Electrical and Electronic Engineering

Fingerprint Dive into the research topics of 'Optically-induced dielectrophoresis using polymer materials for biomedical applications'. Together they form a unique fingerprint.

Cite this