Abstract
In biometric and biomedical applications, a special transporting mechanism must be designed for the micro total analysis system (μTAS) to move samples and reagents through the microchannels that connect the unit procedure components in the system. An important issue for this miniaturization and integration is the microfluid management technique, i.e., microfluid transportation, metering, and mixing. In view of this, an optimal fuzzy sliding-mode control (OFSMC) based on the 8051 microprocessor is designed and a complete microfluidic manipulated biochip system is implemented in this study, with a pneumatic pumping actuator, two feedback-signal photodiodes and flowmeters for better microfluidic management. This new technique successfully improved the efficiency of biochemical reaction by increasing the effective collision into the probe molecules as the target molecules flow back and forth. The new technique was used in DNA extraction. When the number of Escherichia coli cells was 2×102-104 in 25 μl of whole blood, the extraction efficiency of immobilized beads with solution flowing back and forth was 600-fold larger than that of free beads.
| Original language | English |
|---|---|
| Pages (from-to) | 1093-1105 |
| Number of pages | 13 |
| Journal | Control Engineering Practice |
| Volume | 15 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2007 Sep 1 |
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All Science Journal Classification (ASJC) codes
- Control and Systems Engineering
- Computer Science Applications
- Applied Mathematics
- Electrical and Electronic Engineering
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Optimal fuzzy sliding-mode control for bio-microfluidic manipulation. / Chung, Yung Chiang; Wen, Bor Jiunn; Lin, Yu-Cheng.
In: Control Engineering Practice, Vol. 15, No. 9, 01.09.2007, p. 1093-1105.Research output: Contribution to journal › Article
TY - JOUR
T1 - Optimal fuzzy sliding-mode control for bio-microfluidic manipulation
AU - Chung, Yung Chiang
AU - Wen, Bor Jiunn
AU - Lin, Yu-Cheng
PY - 2007/9/1
Y1 - 2007/9/1
N2 - In biometric and biomedical applications, a special transporting mechanism must be designed for the micro total analysis system (μTAS) to move samples and reagents through the microchannels that connect the unit procedure components in the system. An important issue for this miniaturization and integration is the microfluid management technique, i.e., microfluid transportation, metering, and mixing. In view of this, an optimal fuzzy sliding-mode control (OFSMC) based on the 8051 microprocessor is designed and a complete microfluidic manipulated biochip system is implemented in this study, with a pneumatic pumping actuator, two feedback-signal photodiodes and flowmeters for better microfluidic management. This new technique successfully improved the efficiency of biochemical reaction by increasing the effective collision into the probe molecules as the target molecules flow back and forth. The new technique was used in DNA extraction. When the number of Escherichia coli cells was 2×102-104 in 25 μl of whole blood, the extraction efficiency of immobilized beads with solution flowing back and forth was 600-fold larger than that of free beads.
AB - In biometric and biomedical applications, a special transporting mechanism must be designed for the micro total analysis system (μTAS) to move samples and reagents through the microchannels that connect the unit procedure components in the system. An important issue for this miniaturization and integration is the microfluid management technique, i.e., microfluid transportation, metering, and mixing. In view of this, an optimal fuzzy sliding-mode control (OFSMC) based on the 8051 microprocessor is designed and a complete microfluidic manipulated biochip system is implemented in this study, with a pneumatic pumping actuator, two feedback-signal photodiodes and flowmeters for better microfluidic management. This new technique successfully improved the efficiency of biochemical reaction by increasing the effective collision into the probe molecules as the target molecules flow back and forth. The new technique was used in DNA extraction. When the number of Escherichia coli cells was 2×102-104 in 25 μl of whole blood, the extraction efficiency of immobilized beads with solution flowing back and forth was 600-fold larger than that of free beads.
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UR - http://www.scopus.com/inward/citedby.url?scp=34248324462&partnerID=8YFLogxK
U2 - 10.1016/j.conengprac.2007.01.005
DO - 10.1016/j.conengprac.2007.01.005
M3 - Article
VL - 15
SP - 1093
EP - 1105
JO - Control Engineering Practice
JF - Control Engineering Practice
SN - 0967-0661
IS - 9
ER -