TY - JOUR
T1 - Optimal treatment allocation in comparative biomedical studies
AU - Zhu, Wei
AU - Weng, Kee Wong
PY - 2000/3/15
Y1 - 2000/3/15
N2 - In clinical trials involving several treatment protocols, there are usually several objectives of different importance. A general method for finding an optimal design which reflects this practical need is discussed. In particular, we show that the graphical method of Cook and Wong can be applied when there are two objectives. Several illustrative examples are discussed, including multiple-objective designs for comparing several treatment groups with a placebo group. Copyright (C) 2000 John Wiley and Sons, Ltd.
AB - In clinical trials involving several treatment protocols, there are usually several objectives of different importance. A general method for finding an optimal design which reflects this practical need is discussed. In particular, we show that the graphical method of Cook and Wong can be applied when there are two objectives. Several illustrative examples are discussed, including multiple-objective designs for comparing several treatment groups with a placebo group. Copyright (C) 2000 John Wiley and Sons, Ltd.
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U2 - 10.1002/(SICI)1097-0258(20000315)19:5<639::AID-SIM380>3.0.CO;2-K
DO - 10.1002/(SICI)1097-0258(20000315)19:5<639::AID-SIM380>3.0.CO;2-K
M3 - Article
C2 - 10700736
AN - SCOPUS:0034653453
SN - 0277-6715
VL - 19
SP - 639
EP - 648
JO - Statistics in Medicine
JF - Statistics in Medicine
IS - 5
ER -