Optimization of submerged cultivation conditions for production of big cup culinary-medicinal mushroom Clitocybe maxima (Agaricomycetes) biomass with significant antioxidative and antihyperlipidemic activities

Shu Hui Hu, Ker Shew Chen, Ming Yi Liu, Peter Chi Keung Cheung, Jinn Chyi Wang, Sue Joan Chang

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

In this study, a large Clitocybe maxima mycelium biomass was obtained by submerged cultivation under optimal conditions. Three test samples from lyophilized mycelia, including hot water extract (CW) and elutes from solvents with different polarity (CA and CB), were combined and used to explore antioxidant and antihyperlipidemic activities in vitro and in vivo. The CA group showed the highest DPPH free radical scavenging activity and iron-reducing capability at concentrations of 6.0% and 3.0% (w/v), respectively. Further, the CA group showed the highest glutathione peroxidase and superoxide dismutase activities at a dose of 0.25 mg/kg body weight (CA-0.25 group) in all hyperlipidemic hamsters tested. Serum lipid levels (apart from high-density lipoprotein cholesterol levels) of hamsters in the CA-0.25 group were lower than those of hamsters in the negative control group in antihyperlipidemic tests. Therefore, we believe that extracts from C. maxima mycelia are rich reservoirs of antioxidant and antihyperlipidemic activities.

Original languageEnglish
Pages (from-to)641-651
Number of pages11
JournalInternational Journal of Medicinal Mushrooms
Volume19
Issue number7
DOIs
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Applied Microbiology and Biotechnology
  • Pharmacology
  • Drug Discovery

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