Orbital apex syndrome and choroidal metastasis resulting from ovarian carcinoma

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Central nervous system involvement from ovarian cancer is rare, and ovarian cancer-related orbital apex syndrome does not appear to have been previously reported. Only a few cases of choroidal metastases from primary ovarian origin have been reported in the literature. We describe what we believe to be the first case of ovarian cancer with the presentation of orbital apex syndrome and choroidal metastasis as a part of the manifestations. Progressively blurring vision and subsequent ophthalmoplegia of the left eye developed in a 37-year-old woman. Funduscopic examination revealed mild disc edema with flame-shaped hemorrhage and a one disc-sized choroidal mass. Cranial magnetic resonance imaging indicated an ill-defined lesion at the left superior orbital fissure with bony erosion. Systemic evaluation demonstrated an ovarian tumor with multiple organ metastases. Although the ophthalmoplegia cleared completely subsequent to chemotherapy and irradiation, visual acuity still remained the same, with no light-perception. The patient died seven months following the initial diagnosis.

Original languageEnglish
Pages (from-to)9-16
Number of pages8
Issue number1
Publication statusPublished - 2001 Dec 1

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Clinical Neurology


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