Abstract
Several new methods have been used to localize replication initiation sites in mammalian chromosomes. The results of these studies argue strongly for the presence of defined sequence elements that function much like the origins in the genomes of simple microorganisms. However, relatively disparate results from in vivo and in vitro studies suggest that initiation reactions in mammalian chromosomes may have unique features, possibly related to a more complicated chromosomal architecture.
Original language | English |
---|---|
Pages (from-to) | 414-421 |
Number of pages | 8 |
Journal | Current Opinion in Cell Biology |
Volume | 3 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1991 Jun |
All Science Journal Classification (ASJC) codes
- Cell Biology