Origins of replication: timing and chromosomal position

Joyce L. Hamlin, James P. Vaughn, Pieter A. Dijkwel, Tzeng Horng Leu, Chi Ma

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Several new methods have been used to localize replication initiation sites in mammalian chromosomes. The results of these studies argue strongly for the presence of defined sequence elements that function much like the origins in the genomes of simple microorganisms. However, relatively disparate results from in vivo and in vitro studies suggest that initiation reactions in mammalian chromosomes may have unique features, possibly related to a more complicated chromosomal architecture.

Original languageEnglish
Pages (from-to)414-421
Number of pages8
JournalCurrent Opinion in Cell Biology
Issue number3
Publication statusPublished - 1991 Jun

All Science Journal Classification (ASJC) codes

  • Cell Biology


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