Osteopontin polymorphism increases gastric precancerous intestinal metaplasia susceptibility in Helicobacter pylori infected male

Wei-Lun Chang, Meng-Ying Lin, Hsin Yu Kuo, Hsiao Bai Yang, Hsiu-Chi Cheng, Cheng-Chan Lu, Bor-Shyang Sheu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aim: Whether genetic polymorphisms of osteopontin (OPN) coding gene, SPP1, determine the risk of gastric precancerous intestinal metaplasia (IM) in Helicobacter pylori infected patients. Patients & methods: Helicobacter pylori infected patients (100 with and 210 without IM) were recruited to evaluate the associations of SPP1 promoter polymorphisms with gastric IM and adjusted for age, sex and smoking. Gastric OPN expression and inflammation were evaluated by immunohistochemistry, and haemotoxylin and eosin stain. Results: Only in males, but not females, carriage of both GG genotype at rs11730059 and C-G-C haplotype at rs6833161-rs2853744-rs11730582 significantly increased the IM risk (OR: 4.92; 95% CI: 1.65-14.65; p = 0.004). Nearly 87.5% of males with IM carried risky genotype or haplotype. Carriers of the risky genotype or haplotype also had increased gastric OPN expression (p = 0.038) and inflammation (p = 0.007). Conclusion: SPP1 polymorphisms predispose to IM development in H. pylori infected males.

Original languageEnglish
Article number0006
JournalFuture Oncology
Volume13
Issue number16
DOIs
Publication statusPublished - 2017 Jul 1

Fingerprint

Osteopontin
Metaplasia
Helicobacter pylori
Stomach
Haplotypes
Genotype
Inflammation
Genetic Polymorphisms
Hematoxylin
Eosine Yellowish-(YS)
Coloring Agents
Smoking
Immunohistochemistry
Genes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

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title = "Osteopontin polymorphism increases gastric precancerous intestinal metaplasia susceptibility in Helicobacter pylori infected male",
abstract = "Aim: Whether genetic polymorphisms of osteopontin (OPN) coding gene, SPP1, determine the risk of gastric precancerous intestinal metaplasia (IM) in Helicobacter pylori infected patients. Patients & methods: Helicobacter pylori infected patients (100 with and 210 without IM) were recruited to evaluate the associations of SPP1 promoter polymorphisms with gastric IM and adjusted for age, sex and smoking. Gastric OPN expression and inflammation were evaluated by immunohistochemistry, and haemotoxylin and eosin stain. Results: Only in males, but not females, carriage of both GG genotype at rs11730059 and C-G-C haplotype at rs6833161-rs2853744-rs11730582 significantly increased the IM risk (OR: 4.92; 95{\%} CI: 1.65-14.65; p = 0.004). Nearly 87.5{\%} of males with IM carried risky genotype or haplotype. Carriers of the risky genotype or haplotype also had increased gastric OPN expression (p = 0.038) and inflammation (p = 0.007). Conclusion: SPP1 polymorphisms predispose to IM development in H. pylori infected males.",
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Osteopontin polymorphism increases gastric precancerous intestinal metaplasia susceptibility in Helicobacter pylori infected male. / Chang, Wei-Lun; Lin, Meng-Ying; Kuo, Hsin Yu; Yang, Hsiao Bai; Cheng, Hsiu-Chi; Lu, Cheng-Chan; Sheu, Bor-Shyang.

In: Future Oncology, Vol. 13, No. 16, 0006, 01.07.2017.

Research output: Contribution to journalArticle

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AU - Lin, Meng-Ying

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AU - Yang, Hsiao Bai

AU - Cheng, Hsiu-Chi

AU - Lu, Cheng-Chan

AU - Sheu, Bor-Shyang

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N2 - Aim: Whether genetic polymorphisms of osteopontin (OPN) coding gene, SPP1, determine the risk of gastric precancerous intestinal metaplasia (IM) in Helicobacter pylori infected patients. Patients & methods: Helicobacter pylori infected patients (100 with and 210 without IM) were recruited to evaluate the associations of SPP1 promoter polymorphisms with gastric IM and adjusted for age, sex and smoking. Gastric OPN expression and inflammation were evaluated by immunohistochemistry, and haemotoxylin and eosin stain. Results: Only in males, but not females, carriage of both GG genotype at rs11730059 and C-G-C haplotype at rs6833161-rs2853744-rs11730582 significantly increased the IM risk (OR: 4.92; 95% CI: 1.65-14.65; p = 0.004). Nearly 87.5% of males with IM carried risky genotype or haplotype. Carriers of the risky genotype or haplotype also had increased gastric OPN expression (p = 0.038) and inflammation (p = 0.007). Conclusion: SPP1 polymorphisms predispose to IM development in H. pylori infected males.

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