Abstract
Aim: Whether genetic polymorphisms of osteopontin (OPN) coding gene, SPP1, determine the risk of gastric precancerous intestinal metaplasia (IM) in Helicobacter pylori infected patients. Patients & methods: Helicobacter pylori infected patients (100 with and 210 without IM) were recruited to evaluate the associations of SPP1 promoter polymorphisms with gastric IM and adjusted for age, sex and smoking. Gastric OPN expression and inflammation were evaluated by immunohistochemistry, and haemotoxylin and eosin stain. Results: Only in males, but not females, carriage of both GG genotype at rs11730059 and C-G-C haplotype at rs6833161-rs2853744-rs11730582 significantly increased the IM risk (OR: 4.92; 95% CI: 1.65-14.65; p = 0.004). Nearly 87.5% of males with IM carried risky genotype or haplotype. Carriers of the risky genotype or haplotype also had increased gastric OPN expression (p = 0.038) and inflammation (p = 0.007). Conclusion: SPP1 polymorphisms predispose to IM development in H. pylori infected males.
| Original language | English |
|---|---|
| Article number | 0006 |
| Journal | Future Oncology |
| Volume | 13 |
| Issue number | 16 |
| DOIs | |
| Publication status | Published - 2017 Jul 1 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
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Osteopontin polymorphism increases gastric precancerous intestinal metaplasia susceptibility in Helicobacter pylori infected male. / Chang, Wei-Lun; Lin, Meng-Ying; Kuo, Hsin Yu; Yang, Hsiao Bai; Cheng, Hsiu-Chi; Lu, Cheng-Chan; Sheu, Bor-Shyang.
In: Future Oncology, Vol. 13, No. 16, 0006, 01.07.2017.Research output: Contribution to journal › Article
TY - JOUR
T1 - Osteopontin polymorphism increases gastric precancerous intestinal metaplasia susceptibility in Helicobacter pylori infected male
AU - Chang, Wei-Lun
AU - Lin, Meng-Ying
AU - Kuo, Hsin Yu
AU - Yang, Hsiao Bai
AU - Cheng, Hsiu-Chi
AU - Lu, Cheng-Chan
AU - Sheu, Bor-Shyang
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Aim: Whether genetic polymorphisms of osteopontin (OPN) coding gene, SPP1, determine the risk of gastric precancerous intestinal metaplasia (IM) in Helicobacter pylori infected patients. Patients & methods: Helicobacter pylori infected patients (100 with and 210 without IM) were recruited to evaluate the associations of SPP1 promoter polymorphisms with gastric IM and adjusted for age, sex and smoking. Gastric OPN expression and inflammation were evaluated by immunohistochemistry, and haemotoxylin and eosin stain. Results: Only in males, but not females, carriage of both GG genotype at rs11730059 and C-G-C haplotype at rs6833161-rs2853744-rs11730582 significantly increased the IM risk (OR: 4.92; 95% CI: 1.65-14.65; p = 0.004). Nearly 87.5% of males with IM carried risky genotype or haplotype. Carriers of the risky genotype or haplotype also had increased gastric OPN expression (p = 0.038) and inflammation (p = 0.007). Conclusion: SPP1 polymorphisms predispose to IM development in H. pylori infected males.
AB - Aim: Whether genetic polymorphisms of osteopontin (OPN) coding gene, SPP1, determine the risk of gastric precancerous intestinal metaplasia (IM) in Helicobacter pylori infected patients. Patients & methods: Helicobacter pylori infected patients (100 with and 210 without IM) were recruited to evaluate the associations of SPP1 promoter polymorphisms with gastric IM and adjusted for age, sex and smoking. Gastric OPN expression and inflammation were evaluated by immunohistochemistry, and haemotoxylin and eosin stain. Results: Only in males, but not females, carriage of both GG genotype at rs11730059 and C-G-C haplotype at rs6833161-rs2853744-rs11730582 significantly increased the IM risk (OR: 4.92; 95% CI: 1.65-14.65; p = 0.004). Nearly 87.5% of males with IM carried risky genotype or haplotype. Carriers of the risky genotype or haplotype also had increased gastric OPN expression (p = 0.038) and inflammation (p = 0.007). Conclusion: SPP1 polymorphisms predispose to IM development in H. pylori infected males.
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UR - http://www.scopus.com/inward/citedby.url?scp=85026904603&partnerID=8YFLogxK
U2 - 10.2217/fon-2017-0006
DO - 10.2217/fon-2017-0006
M3 - Article
C2 - 28685609
AN - SCOPUS:85026904603
VL - 13
JO - Future Oncology
JF - Future Oncology
SN - 1479-6694
IS - 16
M1 - 0006
ER -