Outcome and prognosis of anaplastic large cell lymphoma in children: a report from the Taiwan Pediatric Oncology Group

Shih Hsiang Chen, Jiann Shiuh Chen, Shiann Tarng Jou, Kang Hsi Wu, Iou Jih Hung, Jiunn Ming Sheen, Meng Yao Lu, Bow Wen Chen, Tang Her Jaing, Shih Chung Wang, Ming Tsan Lin, Te Kau Chang, Hsi Che Liu, Chao Ping Yang

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Abstract

Studies of childhood anaplastic large cell lymphoma (ALCL) are less reported from East Asian countries. Clinical features and outcome of 90 children with ALCL in Taiwan were analyzed. The median age at diagnosis was 11.7 years. The most common presentation was lymph node involvement (86.7%). Advanced diseases accounted for 70% of patients at diagnosis. Most patients (93.1%) had positive staining for anaplastic lymphoma kinase. The five-year overall survival and event-free survival (EFS) rates were 79.7% and 73.3%, respectively. Bone marrow involvement, advanced stage, and thoracopulmonary ALCL were adverse prognostic factors for EFS (p=.05,.04, and.03, respectively). In multivariate analysis, only thoracopulmonary ALCL had a marginal significance on worse EFS (p= .054). We suggested that children with thoracopulmonary ALCL may need to intensify the treatment, and introduction of new targeted therapies for relapsed/refractory disease will be required.

Original languageEnglish
Pages (from-to)1942-1949
Number of pages8
JournalLeukemia and Lymphoma
Volume60
Issue number8
DOIs
Publication statusPublished - 2019 Jul 3

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All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Chen, S. H., Chen, J. S., Jou, S. T., Wu, K. H., Hung, I. J., Sheen, J. M., Lu, M. Y., Chen, B. W., Jaing, T. H., Wang, S. C., Lin, M. T., Chang, T. K., Liu, H. C., & Yang, C. P. (2019). Outcome and prognosis of anaplastic large cell lymphoma in children: a report from the Taiwan Pediatric Oncology Group. Leukemia and Lymphoma, 60(8), 1942-1949. https://doi.org/10.1080/10428194.2018.1562182