Outcome of 3-day bleomycin, etoposide and cisplatin chemotherapeutic regimen for patients with malignant ovarian germ cell tumours: A Taiwanese Gynecologic Oncology Group study

Chi An Chen, Hao Lin, Chia Sui Weng, Kuo Chang Wen, Chien Hsing Lu, Hung Hsueh Chou, Yu Fang Huang, Chieh Yi Kang, Chih Ming Ho, Mu Hsien Yu, Cheng Yang Chou

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8 Citations (Scopus)

Abstract

Background The combination of bleomycin, etoposide and cisplatin (BEP) is currently the most widely used treatment for malignant ovarian germ cell tumours (MOGCTs). The aim of this study was to evaluate the efficacy and adverse effects of the 3-day BEP regimen in Taiwan. The prognostic factors of the MOGCT patients were also analysed. Patients and methods Two hundred and thirty-nine cases of MOGCTs were identified from the Taiwanese Gynecologic Oncology Group database, and 204 of those who received postoperative BEP chemotherapy were then analysed. Results The estimated rate of no evidence of disease was 94.0% for 204 patients with adjuvant BEP regimen. Seven grade 3/4 haematological adverse effects including four subjects with neutropenia, one with pancytopenia and two with neutropenic fever were recorded in the 853 total courses of chemotherapeutic cycles. The rates of haematological and non-haematological adverse effects were 0.82% and 2.3%, respectively. No treatment-related mortality was noted. In the analysis of prognostic factors, only tumour stage had a significant impact on disease recurrence (95% confidence interval (CI), 4.2-94.4, p < 0.001) and disease-related mortality (95% CI, 2.2-163.9, p = 0.007). Conclusions The current 3-day adjuvant BEP regimen was effective and safe for patients with MOGCTs.

Original languageEnglish
Pages (from-to)3161-3167
Number of pages7
JournalEuropean Journal of Cancer
Volume50
Issue number18
DOIs
Publication statusPublished - 2014 Dec

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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