Outcome of ovarian preservation during surgical treatment for endometrial cancer

A Taiwanese Gynecologic Oncology Group study

Hei Yu Lau, Min Yu Chen, Yu Min Ke, Jen Ruei Chen, I. Hui Chen, Wen Shiung Liou, Hung Chun Fu, Cheng Chang Chang, Keng-Fu Hsu, Kung Liahng Wang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: The goal of this study was to investigate the impact of ovarian preservation on the survival of women with early-stage endometrial cancer, particularly young women. Materials and methods: A study cohort of 64 patients with histologically confirmed early-stage endometrial cancer was retrospectively collected from 10 member hospitals of the Taiwanese Gynecologic Oncology Group between 1998 and 2009. Survivorship and overall survival were compared between these two groups using a log-rank test. Results: All patients who underwent surgery were adult women with a mean age of 40.4 ± 9.2 years (range 24-63 years). Ovary-preserving surgery was performed in 38 (59.4%) patients who desired to preserve their ovaries, incidentally in 19 (29.7%) patients with a preoperative diagnosis other than endometrial carcinoma, and in seven patients (10.9%) with unknown reasons. The 5-year recurrence-free survival rate was 98.3% with a median follow up of 44.6 months (range 1.0-126.9 months). Eight patients required adjuvant treatment (12.5%); one patient had documented local recurrence (1.6%); and no metachronous ovarian malignancy occurred during follow up. Conclusion: Preservation of bilateral ovaries does not increase cancer-related mortality. A more conservative approach to surgical staging may be considered in premenopausal women with early-stage endometrial cancer without risk factors.

Original languageEnglish
Pages (from-to)532-536
Number of pages5
JournalTaiwanese Journal of Obstetrics and Gynecology
Volume54
Issue number5
DOIs
Publication statusPublished - 2015 Oct 1

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Endometrial Neoplasms
Ovary
Therapeutics
Survival Rate
Recurrence
Survival
Neoplasms
Cohort Studies
Mortality

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

Lau, Hei Yu ; Chen, Min Yu ; Ke, Yu Min ; Chen, Jen Ruei ; Chen, I. Hui ; Liou, Wen Shiung ; Fu, Hung Chun ; Chang, Cheng Chang ; Hsu, Keng-Fu ; Wang, Kung Liahng. / Outcome of ovarian preservation during surgical treatment for endometrial cancer : A Taiwanese Gynecologic Oncology Group study. In: Taiwanese Journal of Obstetrics and Gynecology. 2015 ; Vol. 54, No. 5. pp. 532-536.
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abstract = "Objective: The goal of this study was to investigate the impact of ovarian preservation on the survival of women with early-stage endometrial cancer, particularly young women. Materials and methods: A study cohort of 64 patients with histologically confirmed early-stage endometrial cancer was retrospectively collected from 10 member hospitals of the Taiwanese Gynecologic Oncology Group between 1998 and 2009. Survivorship and overall survival were compared between these two groups using a log-rank test. Results: All patients who underwent surgery were adult women with a mean age of 40.4 ± 9.2 years (range 24-63 years). Ovary-preserving surgery was performed in 38 (59.4{\%}) patients who desired to preserve their ovaries, incidentally in 19 (29.7{\%}) patients with a preoperative diagnosis other than endometrial carcinoma, and in seven patients (10.9{\%}) with unknown reasons. The 5-year recurrence-free survival rate was 98.3{\%} with a median follow up of 44.6 months (range 1.0-126.9 months). Eight patients required adjuvant treatment (12.5{\%}); one patient had documented local recurrence (1.6{\%}); and no metachronous ovarian malignancy occurred during follow up. Conclusion: Preservation of bilateral ovaries does not increase cancer-related mortality. A more conservative approach to surgical staging may be considered in premenopausal women with early-stage endometrial cancer without risk factors.",
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Outcome of ovarian preservation during surgical treatment for endometrial cancer : A Taiwanese Gynecologic Oncology Group study. / Lau, Hei Yu; Chen, Min Yu; Ke, Yu Min; Chen, Jen Ruei; Chen, I. Hui; Liou, Wen Shiung; Fu, Hung Chun; Chang, Cheng Chang; Hsu, Keng-Fu; Wang, Kung Liahng.

In: Taiwanese Journal of Obstetrics and Gynecology, Vol. 54, No. 5, 01.10.2015, p. 532-536.

Research output: Contribution to journalArticle

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T2 - A Taiwanese Gynecologic Oncology Group study

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AU - Ke, Yu Min

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AU - Chen, I. Hui

AU - Liou, Wen Shiung

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N2 - Objective: The goal of this study was to investigate the impact of ovarian preservation on the survival of women with early-stage endometrial cancer, particularly young women. Materials and methods: A study cohort of 64 patients with histologically confirmed early-stage endometrial cancer was retrospectively collected from 10 member hospitals of the Taiwanese Gynecologic Oncology Group between 1998 and 2009. Survivorship and overall survival were compared between these two groups using a log-rank test. Results: All patients who underwent surgery were adult women with a mean age of 40.4 ± 9.2 years (range 24-63 years). Ovary-preserving surgery was performed in 38 (59.4%) patients who desired to preserve their ovaries, incidentally in 19 (29.7%) patients with a preoperative diagnosis other than endometrial carcinoma, and in seven patients (10.9%) with unknown reasons. The 5-year recurrence-free survival rate was 98.3% with a median follow up of 44.6 months (range 1.0-126.9 months). Eight patients required adjuvant treatment (12.5%); one patient had documented local recurrence (1.6%); and no metachronous ovarian malignancy occurred during follow up. Conclusion: Preservation of bilateral ovaries does not increase cancer-related mortality. A more conservative approach to surgical staging may be considered in premenopausal women with early-stage endometrial cancer without risk factors.

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