Overexpression of c-erb-B2 proteins in tumor and non-tumor parts of gastric adenocarcinoma - Emphasis on its relation to H. pylori infection and clinicohistological characteristics

Yen Lin Wang, Bor-Shyang Sheu, Hsiao Bai Yang, Pin Wen Lin, Yu Chung Chang

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25 Citations (Scopus)

Abstract

Background/Aims: This study was designed to test whether c-erb-B2 overexpression can be related to H. pylori infection or clinicohistological characteristics of patients with gastric cancers. Methodology: One hundred patients with gastric cancer were included. Their gastric specimens were evaluated for the presence of H. pylori infection and overexpression of c-erb-B2 on both tumor and non-tumor mucosa. The clinicohistological characteristics, including stage, histological subtype, cell differentiation, and locations of gastric cancer were reviewed. Results: Seventy-five patients (75%) had H. pylori infection. The H. pylori infection rate was higher in the patients with non-cardiac cancers than those with cardiac cancers (87.5% vs. 25%, P<0.05); higher in the patients with intestinal-type cancers than those with diffuse-type cancers (78.8% vs. 53.3%, P<0.05). The overexpression of c-erb-B2 on gastric cancers was not significantly different between patients with and without H. pylori infection (30.7% vs. 36%, P=NS). Overexpression of c-erb-B2 on the gastric cancer tissues increased as the tumor stage turned upward (stage I: 10%; II: 23.3%, III: 32.5%, IV: 55%, P<0.05), and highest in the poorly differentiated cancers (56.6%). Only patients with advanced stages as II to IV had c-erb-B2 overexpression on the non-tumor part of stomach (P<0.05). Conclusions: H. pylori infection is closely related with the non-cardiac, intestinal-type gastric cancers, but not with the c-erb-B2 overexpression on the gastric cancer. As c-erb-B2 overexpression on gastric cancer is significantly related with poor tumor differentiation and advanced stage, and it thus implicates a poor prognosis and late event of carcinogenesis.

Original languageEnglish
Pages (from-to)1172-1176
Number of pages5
JournalHepato-Gastroenterology
Volume49
Issue number46
Publication statusPublished - 2002 Aug 5

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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