Oxidative Stress and Frailty: A Closer Look at the Origin of a Human Aging Phenotype

I. Chien Wu, Chao A. Hsiung, Chih Cheng Hsu, Xi-Zhang Lin

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Frailty is an important health problem for older adults. Its clinical significance is increasingly being demonstrated and recognized. The pathogenesis of frailty involves insulin resistance, inflammation, sarcopenia, adiposity, age-related hormone decline, and nervous system dysfunction. What remains unclear is how these abnormalities of multiple physiologic systems occur as we age. The answer may lie in the increased oxidative stress that occurs during aging. Correlative human studies using different markers of oxidative stress consistently showed that increased oxidative stress independently predicts frailty. Transgenic mice with high oxidative stress display pathologies and phenotypes resembling those of frailty. Oxidative stress can cause frailty by the following cellular mechanisms: mitochondrial dysfunction; damage to proteins critical for maintaining homeostasis and muscle function; endoplasmic reticulum (ER) stress; cellular apoptosis; cellular senescence; and abnormal cellular signaling. Oxidative stress and its downstream cellular pathogenic pathways may offer the targets for prevention and intervention strategies against frailty. Further studies are required in this field.

Original languageEnglish
Title of host publicationAging
Subtitle of host publicationOxidative Stress and Dietary Antioxidants
PublisherElsevier Inc.
Pages3-14
Number of pages12
ISBN (Print)9780124059337
DOIs
Publication statusPublished - 2014 Jan 1

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Oxidative Stress
Phenotype
Sarcopenia
Multiple Abnormalities
Endoplasmic Reticulum Stress
Cell Aging
Adiposity
Nervous System
Transgenic Mice
Insulin Resistance
Homeostasis
Hormones
Apoptosis
Pathology
Inflammation
Muscles
Health
Proteins

All Science Journal Classification (ASJC) codes

  • Dentistry(all)
  • Medicine(all)

Cite this

Wu, I. C., Hsiung, C. A., Hsu, C. C., & Lin, X-Z. (2014). Oxidative Stress and Frailty: A Closer Look at the Origin of a Human Aging Phenotype. In Aging: Oxidative Stress and Dietary Antioxidants (pp. 3-14). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-405933-7.00001-9
Wu, I. Chien ; Hsiung, Chao A. ; Hsu, Chih Cheng ; Lin, Xi-Zhang. / Oxidative Stress and Frailty : A Closer Look at the Origin of a Human Aging Phenotype. Aging: Oxidative Stress and Dietary Antioxidants. Elsevier Inc., 2014. pp. 3-14
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Wu, IC, Hsiung, CA, Hsu, CC & Lin, X-Z 2014, Oxidative Stress and Frailty: A Closer Look at the Origin of a Human Aging Phenotype. in Aging: Oxidative Stress and Dietary Antioxidants. Elsevier Inc., pp. 3-14. https://doi.org/10.1016/B978-0-12-405933-7.00001-9

Oxidative Stress and Frailty : A Closer Look at the Origin of a Human Aging Phenotype. / Wu, I. Chien; Hsiung, Chao A.; Hsu, Chih Cheng; Lin, Xi-Zhang.

Aging: Oxidative Stress and Dietary Antioxidants. Elsevier Inc., 2014. p. 3-14.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Wu IC, Hsiung CA, Hsu CC, Lin X-Z. Oxidative Stress and Frailty: A Closer Look at the Origin of a Human Aging Phenotype. In Aging: Oxidative Stress and Dietary Antioxidants. Elsevier Inc. 2014. p. 3-14 https://doi.org/10.1016/B978-0-12-405933-7.00001-9