Oxidative stress participates in quadriceps muscle dysfunction during the initiation of osteoarthritis in rats

Dur Zong Hsu, Pei Yi Chu, Po Ting Wu, Po Chuan Shen, I. Ming Jou

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Osteoarthritis is the most common form of arthritis, affecting approximately 15% of the population. Quadriceps muscle weakness is one of the risk factors of osteoarthritis development. Oxidative stress has been reported to play an important role in the pathogenesis of various muscle dysfunction; however, whether it is involved in osteoarthritis-associated quadriceps muscle weakness has never been investigated. The aim of the present study is to examine the involvement of oxidative stress in quadriceps muscle dysfunction in the initiation of osteoarthritis in rats. Rat osteoarthritis was initiated by conducting meniscectomy (MNX). Quadriceps muscle dysfunction was evaluated by assessing muscular interleukin-6, citrate synthase activity, and myosin heavy chain IIa mRNA expression levels. Muscular oxidative stress was assessed by determining lipid peroxidation, Nrf2 expression, reactive oxygen species, and circulating antioxidants. Increased muscular interleukin-6 production as well as decreased citrate synthase activity and myosin heavy chain IIa mRNA expression were observed at 7 and 14 days after MNX. Biomarkers of oxidative stress were significantly increased after MNX. Muscular free radical counts were increased while glutathione and glutathione peroxidase expression were decreased in MNX-treated rats. We conclude that oxidative stress may be involved in the pathogenesis of muscle dysfunction in MNX-induced osteoarthritis.

Original languageEnglish
Pages (from-to)12491-12499
Number of pages9
JournalInternational Journal of Clinical and Experimental Pathology
Issue number10
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology


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