Low density lipoproteins are natural nanoparticles derived from lipid metabolism. Ox-LDLs are generated by LDLs ongoing auto-oxidation. It has been shown that oxLDL induced apoptosis of endothelial cells and is highly associated with arthrosclerosis and other cardiovascular diseases. Our study demonstrated ox-LDLs not only induce endothelial cell apoptosis but also promote tumor ceDs ongoing apoptosis. Measurement of mitochondrial membrane potential (ΔΨ) revealed a significant loss of the ΔΨ upon exposure to oxLDL and a dose dependency was observed. Further exploration to redirect oxLDL as an alternative cancer cell targeting chemotherapeutic agent and anti-cancer drug carrier could be a potential new therapeutic strategy.