TY - JOUR
T1 - Oxytocin receptor signaling in the hippocampus
T2 - Role in regulating neuronal excitability, network oscillatory activity, synaptic plasticity and social memory
AU - Lin, Yu Ting
AU - Hsu, Kuei Sen
N1 - Funding Information:
The authors thank R. C. Froemke for critical input on preparing the manuscript. This work was partially supported by research grants from the Ministry of Science and Technology ( 106-2320-B-006-026-MY3 ; 107-2320-B-006-037-MY3 ) and the National Health Research Institute ( NHRI-EX107-10713NI ), Taiwan.
Funding Information:
The authors thank R. C. Froemke for critical input on preparing the manuscript. This work was partially supported by research grants from the Ministry of Science and Technology (106-2320-B-006-026-MY3; 107-2320-B-006-037-MY3) and the National Health Research Institute (NHRI-EX107-10713NI), Taiwan.
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/12
Y1 - 2018/12
N2 - Beyond its well-known role in reproduction, the hypothalamic neuropeptide oxytocin (OXT) has been implicated in a broad spectrum of social and nonsocial behaviors. The biological actions of OXT are exerted through specific OXT receptors (OXTR) that belong to the family of G protein-coupled receptors. OXTR is abundantly expressed in the hippocampus, and the past decade has witnessed tremendous progress in our understanding of the physiological significance of hippocampal OXTR signaling. In this review, we mainly focus on recent progress made in identifying the role of hippocampal OXTR signaling in regulating neuronal excitability, network oscillatory activity, synaptic plasticity and social recognition memory. We also discuss recent insights into the cellular mechanisms underlying these processes regulated by OXTR signaling. Finally, we discuss the remaining questions for future research. A full understanding of the functional role of hippocampal OXTR signaling may lead to targeted new therapies for social cognition deficits, often observed in patients with autism and other neuropsychiatric disorders.
AB - Beyond its well-known role in reproduction, the hypothalamic neuropeptide oxytocin (OXT) has been implicated in a broad spectrum of social and nonsocial behaviors. The biological actions of OXT are exerted through specific OXT receptors (OXTR) that belong to the family of G protein-coupled receptors. OXTR is abundantly expressed in the hippocampus, and the past decade has witnessed tremendous progress in our understanding of the physiological significance of hippocampal OXTR signaling. In this review, we mainly focus on recent progress made in identifying the role of hippocampal OXTR signaling in regulating neuronal excitability, network oscillatory activity, synaptic plasticity and social recognition memory. We also discuss recent insights into the cellular mechanisms underlying these processes regulated by OXTR signaling. Finally, we discuss the remaining questions for future research. A full understanding of the functional role of hippocampal OXTR signaling may lead to targeted new therapies for social cognition deficits, often observed in patients with autism and other neuropsychiatric disorders.
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U2 - 10.1016/j.pneurobio.2018.10.003
DO - 10.1016/j.pneurobio.2018.10.003
M3 - Review article
C2 - 30359747
AN - SCOPUS:85055977096
SN - 0301-0082
VL - 171
SP - 1
EP - 14
JO - Progress in Neurobiology
JF - Progress in Neurobiology
ER -