p120RasGAP-mediated activation of c-Src is critical for oncogenic ras to induce tumor invasion

Po Chao Chan, Hong Chen Chen

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Ras genes are the most common targets for somatic gain-of-function mutations in human cancers. In this study, we found a high incidence of correlation between Ras oncogenic mutations and c-Src activation in human cancer cells. We showed that oncogenic Ras induces c-Src activation mainly on the Golgi complex and endoplasmic reticulum. Moreover, we identified p120RasGAP as an effector for oncogenic Ras to activate c-Src. The recruitment of p120RasGAP to the Golgi complex by oncogenic Ras facilitated its interaction with c-Src, thereby leading to c-Src activation, and this p120RasGAP-mediated activation of c-Src was important for tumor invasion induced by oncogenic Ras. Collectively, our findings unveil a relationship between oncogenic Ras, p120RasGAP, and c-Src, suggesting a critical role for c-Src in cancers evoked by oncogenic mutations in Ras genes.

Original languageEnglish
Pages (from-to)2405-2415
Number of pages11
JournalCancer Research
Volume72
Issue number9
DOIs
Publication statusPublished - 2012 May 1

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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