TY - JOUR
T1 - p120RasGAP-mediated activation of c-Src is critical for oncogenic ras to induce tumor invasion
AU - Chan, Po Chao
AU - Chen, Hong Chen
PY - 2012/5/1
Y1 - 2012/5/1
N2 - Ras genes are the most common targets for somatic gain-of-function mutations in human cancers. In this study, we found a high incidence of correlation between Ras oncogenic mutations and c-Src activation in human cancer cells. We showed that oncogenic Ras induces c-Src activation mainly on the Golgi complex and endoplasmic reticulum. Moreover, we identified p120RasGAP as an effector for oncogenic Ras to activate c-Src. The recruitment of p120RasGAP to the Golgi complex by oncogenic Ras facilitated its interaction with c-Src, thereby leading to c-Src activation, and this p120RasGAP-mediated activation of c-Src was important for tumor invasion induced by oncogenic Ras. Collectively, our findings unveil a relationship between oncogenic Ras, p120RasGAP, and c-Src, suggesting a critical role for c-Src in cancers evoked by oncogenic mutations in Ras genes.
AB - Ras genes are the most common targets for somatic gain-of-function mutations in human cancers. In this study, we found a high incidence of correlation between Ras oncogenic mutations and c-Src activation in human cancer cells. We showed that oncogenic Ras induces c-Src activation mainly on the Golgi complex and endoplasmic reticulum. Moreover, we identified p120RasGAP as an effector for oncogenic Ras to activate c-Src. The recruitment of p120RasGAP to the Golgi complex by oncogenic Ras facilitated its interaction with c-Src, thereby leading to c-Src activation, and this p120RasGAP-mediated activation of c-Src was important for tumor invasion induced by oncogenic Ras. Collectively, our findings unveil a relationship between oncogenic Ras, p120RasGAP, and c-Src, suggesting a critical role for c-Src in cancers evoked by oncogenic mutations in Ras genes.
UR - http://www.scopus.com/inward/record.url?scp=84860535263&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860535263&partnerID=8YFLogxK
U2 - 10.1158/0008-5472.CAN-11-3078
DO - 10.1158/0008-5472.CAN-11-3078
M3 - Article
C2 - 22411953
AN - SCOPUS:84860535263
SN - 0008-5472
VL - 72
SP - 2405
EP - 2415
JO - Cancer Research
JF - Cancer Research
IS - 9
ER -