p53 expression in pterygium by immunohistochemical analysis: A series report of 127 cases and review of the literature

Yi Yu Tsai, Kong Chao Chang, Chien Lin Lin, Huei Lee, Fun Jen Tsai, Ya Wen Cheng, Sung Huei Tseng

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Purpose: To assess the p53 protein expression in pterygial tissue and to review all immunohistochemical studies on pterygium from Medline to evaluate the roles of age, gender, race, p53 antibody, cutoff levels of immunohistochemical analysis, parts of pterygium, p53 gene mutation spectrum, and primary or recurrent pterygium on the p53 staining results. Methods: Immunohistochemical staining was performed on 127 pterygial specimens and 18 normal conjunctival samples. All 8 immunohistochemical studies on p53 expression in pterygium from Medline were reviewed. Results: Among the 127 pterygial samples, there were 29 specimens (22.8%) positive for p53 expression. There was no significant difference between the p53-positive and p53-negative groups with respect to age or gender. Conclusion: The positive rate of p53 staining in 8 immunohistochemical studies was 7.9%, 36.8%, 37.5%, 38.1%, 50%, 53.8%, 60%, and 100%, respectively. p53 protein antibody, cutoff level, race, and p53 gene mutational spectra all affect the results on the p53 staining. Different parts of pterygium and gender merit further evaluation in their role on p53 staining result.

Original languageEnglish
Pages (from-to)583-586
Number of pages4
JournalCornea
Volume24
Issue number5
DOIs
Publication statusPublished - 2005 Jul 1

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Pterygium
Staining and Labeling
p53 Genes
Antibodies
Proteins
Mutation

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Tsai, Yi Yu ; Chang, Kong Chao ; Lin, Chien Lin ; Lee, Huei ; Tsai, Fun Jen ; Cheng, Ya Wen ; Tseng, Sung Huei. / p53 expression in pterygium by immunohistochemical analysis : A series report of 127 cases and review of the literature. In: Cornea. 2005 ; Vol. 24, No. 5. pp. 583-586.
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abstract = "Purpose: To assess the p53 protein expression in pterygial tissue and to review all immunohistochemical studies on pterygium from Medline to evaluate the roles of age, gender, race, p53 antibody, cutoff levels of immunohistochemical analysis, parts of pterygium, p53 gene mutation spectrum, and primary or recurrent pterygium on the p53 staining results. Methods: Immunohistochemical staining was performed on 127 pterygial specimens and 18 normal conjunctival samples. All 8 immunohistochemical studies on p53 expression in pterygium from Medline were reviewed. Results: Among the 127 pterygial samples, there were 29 specimens (22.8{\%}) positive for p53 expression. There was no significant difference between the p53-positive and p53-negative groups with respect to age or gender. Conclusion: The positive rate of p53 staining in 8 immunohistochemical studies was 7.9{\%}, 36.8{\%}, 37.5{\%}, 38.1{\%}, 50{\%}, 53.8{\%}, 60{\%}, and 100{\%}, respectively. p53 protein antibody, cutoff level, race, and p53 gene mutational spectra all affect the results on the p53 staining. Different parts of pterygium and gender merit further evaluation in their role on p53 staining result.",
author = "Tsai, {Yi Yu} and Chang, {Kong Chao} and Lin, {Chien Lin} and Huei Lee and Tsai, {Fun Jen} and Cheng, {Ya Wen} and Tseng, {Sung Huei}",
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p53 expression in pterygium by immunohistochemical analysis : A series report of 127 cases and review of the literature. / Tsai, Yi Yu; Chang, Kong Chao; Lin, Chien Lin; Lee, Huei; Tsai, Fun Jen; Cheng, Ya Wen; Tseng, Sung Huei.

In: Cornea, Vol. 24, No. 5, 01.07.2005, p. 583-586.

Research output: Contribution to journalReview article

TY - JOUR

T1 - p53 expression in pterygium by immunohistochemical analysis

T2 - A series report of 127 cases and review of the literature

AU - Tsai, Yi Yu

AU - Chang, Kong Chao

AU - Lin, Chien Lin

AU - Lee, Huei

AU - Tsai, Fun Jen

AU - Cheng, Ya Wen

AU - Tseng, Sung Huei

PY - 2005/7/1

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AB - Purpose: To assess the p53 protein expression in pterygial tissue and to review all immunohistochemical studies on pterygium from Medline to evaluate the roles of age, gender, race, p53 antibody, cutoff levels of immunohistochemical analysis, parts of pterygium, p53 gene mutation spectrum, and primary or recurrent pterygium on the p53 staining results. Methods: Immunohistochemical staining was performed on 127 pterygial specimens and 18 normal conjunctival samples. All 8 immunohistochemical studies on p53 expression in pterygium from Medline were reviewed. Results: Among the 127 pterygial samples, there were 29 specimens (22.8%) positive for p53 expression. There was no significant difference between the p53-positive and p53-negative groups with respect to age or gender. Conclusion: The positive rate of p53 staining in 8 immunohistochemical studies was 7.9%, 36.8%, 37.5%, 38.1%, 50%, 53.8%, 60%, and 100%, respectively. p53 protein antibody, cutoff level, race, and p53 gene mutational spectra all affect the results on the p53 staining. Different parts of pterygium and gender merit further evaluation in their role on p53 staining result.

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