Painless skin electroporation as a novel way for insulin delivery

Tak Wah Wong; Tai Yu Chen; Chien Chun Huang; Jui Chen Tsai; Sek Wen Hui

doi:10.1089/dia.2011.0077

Painless skin electroporation as a novel way for insulin delivery

Tak Wah Wong, Tai Yu Chen, Chien Chun Huang, Jui Chen Tsai, Sek Wen Hui

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Background: Rigorous research efforts have been undertaken worldwide to develop a needle-free insulin delivery for many decades with limited success. This translational study aims to deliver insulin through skin with painless electroporation. Methods: A recently designed microelectrode array was used to deliver insulin in mice with diabetes under electroporation conditions that are painless and harmless on human skin. Results: Under such condition, a therapeutic amount of insulin was delivered successfully through mouse skin. Electroporation alone increased insulin transport around 100-fold compared with passive diffusion. Increased skin temperature to 40°C for 20 min augmented insulin transport to 237-fold more than the control value. Repeated electroporation showed no harm on human skin. Conclusion: The results indicate the potential of painless delivery of insulin through human skin in future clinical practice.

Original language	English
Pages (from-to)	929-935
Number of pages	7
Journal	Diabetes Technology and Therapeutics
Volume	13
Issue number	9
DOIs	https://doi.org/10.1089/dia.2011.0077
Publication status	Published - 2011 Sept 1

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Endocrinology
Medical Laboratory Technology

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10.1089/dia.2011.0077

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abstract = "Background: Rigorous research efforts have been undertaken worldwide to develop a needle-free insulin delivery for many decades with limited success. This translational study aims to deliver insulin through skin with painless electroporation. Methods: A recently designed microelectrode array was used to deliver insulin in mice with diabetes under electroporation conditions that are painless and harmless on human skin. Results: Under such condition, a therapeutic amount of insulin was delivered successfully through mouse skin. Electroporation alone increased insulin transport around 100-fold compared with passive diffusion. Increased skin temperature to 40°C for 20 min augmented insulin transport to 237-fold more than the control value. Repeated electroporation showed no harm on human skin. Conclusion: The results indicate the potential of painless delivery of insulin through human skin in future clinical practice.",

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AU - Wong, Tak Wah

AU - Chen, Tai Yu

AU - Huang, Chien Chun

AU - Tsai, Jui Chen

AU - Hui, Sek Wen

PY - 2011/9/1

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Painless skin electroporation as a novel way for insulin delivery

Abstract

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