Palladium-catalyzed dehalogenation of 5-halopyrazoles

Chun-Yen Chen, Yu Ying Huang, Wei Nien Su, Kimiyoshi Kaneko, Masayuki Kimura, Hiroyuki Takayama, Fung Fuh Wong

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A new and efficient method for the dehalogenation of 5-halopyrazoles was developed by using the catalytic amount of palladium (II) chloride and triphenylphosphine as a ligand at reflux under constant flow of hydrogen gas. The reaction gave the corresponding pyrazole products in good to excellent yields (≥83%)..

Original languageEnglish
Pages (from-to)183-189
Number of pages7
JournalJournal of Heterocyclic Chemistry
Volume49
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1

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Dehalogenation
Palladium
Chlorides
Hydrogen
Gases
Ligands
triphenylphosphine
pyrazole

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

Chen, C-Y., Huang, Y. Y., Su, W. N., Kaneko, K., Kimura, M., Takayama, H., & Wong, F. F. (2012). Palladium-catalyzed dehalogenation of 5-halopyrazoles. Journal of Heterocyclic Chemistry, 49(1), 183-189. https://doi.org/10.1002/jhet.845
Chen, Chun-Yen ; Huang, Yu Ying ; Su, Wei Nien ; Kaneko, Kimiyoshi ; Kimura, Masayuki ; Takayama, Hiroyuki ; Wong, Fung Fuh. / Palladium-catalyzed dehalogenation of 5-halopyrazoles. In: Journal of Heterocyclic Chemistry. 2012 ; Vol. 49, No. 1. pp. 183-189.
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Chen, C-Y, Huang, YY, Su, WN, Kaneko, K, Kimura, M, Takayama, H & Wong, FF 2012, 'Palladium-catalyzed dehalogenation of 5-halopyrazoles', Journal of Heterocyclic Chemistry, vol. 49, no. 1, pp. 183-189. https://doi.org/10.1002/jhet.845

Palladium-catalyzed dehalogenation of 5-halopyrazoles. / Chen, Chun-Yen; Huang, Yu Ying; Su, Wei Nien; Kaneko, Kimiyoshi; Kimura, Masayuki; Takayama, Hiroyuki; Wong, Fung Fuh.

In: Journal of Heterocyclic Chemistry, Vol. 49, No. 1, 01.01.2012, p. 183-189.

Research output: Contribution to journalArticle

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Chen C-Y, Huang YY, Su WN, Kaneko K, Kimura M, Takayama H et al. Palladium-catalyzed dehalogenation of 5-halopyrazoles. Journal of Heterocyclic Chemistry. 2012 Jan 1;49(1):183-189. https://doi.org/10.1002/jhet.845