Pancreas-Brain Crosstalk

Battuvshin Lkhagvasuren, Onanong Mee-inta, Zi Wei Zhao, Tetsuya Hiramoto, Damdindorj Boldbaatar, Yu Min Kuo

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)

Abstract

The neural regulation of glucose homeostasis in normal and challenged conditions involves the modulation of pancreatic islet-cell function. Compromising the pancreas innervation causes islet autoimmunity in type 1 diabetes and islet cell dysfunction in type 2 diabetes. However, despite the richly innervated nature of the pancreas, islet innervation remains ill-defined. Here, we review the neuroanatomical and humoral basis of the cross-talk between the endocrine pancreas and autonomic and sensory neurons. Identifying the neurocircuitry and neurochemistry of the neuro-insular network would provide clues to neuromodulation-based approaches for the prevention and treatment of diabetes and obesity.

Original languageEnglish
Article number691777
JournalFrontiers in Neuroanatomy
Volume15
DOIs
Publication statusPublished - 2021 Jul 20

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Neuroscience (miscellaneous)
  • Cellular and Molecular Neuroscience

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