TY - JOUR
T1 - Pancreatic enzymes in uremic patients with or without dialysis
AU - Lin, Xi Zhang
AU - Chen, Tzen Wen
AU - Wang, Sun Sang
AU - Shiesh, Shu Chu
AU - Tsai, Yang Te
AU - Huang, Tung Po
AU - Lee, Shou Dong
AU - Wen-Kao Ting, Stanford
N1 - Funding Information:
The authors thank Dr. Ting-Shi Wang and Mr. Wen-Yu Cheng for data collection, Meei-Ju Chiu and Wen-Chia Chen for technical assistance, and Tseng-Ming Tsai, Ph.D., associate professor of mathematics in the National Taiwan University for statistical consultation. The research is supported by the Research Foundation of Veterans General Hospital, Taipei.
PY - 1988/6
Y1 - 1988/6
N2 - One hundred thirty blood samples from 87 patients with renal failure, but without abdominal pain, were analyzed for blood urea nitrogen (BUN), creatinine, amylase, p-isoamylase, and lipase simultaneously. We found that 74, 78, and 80% of the patients had hyperamylasemia, hyperisoamylasemia, and hyperlipasemia. None had amylase higher than five times the upper limit. A few patients (2.3%) had lipase elevated to more than 10 times the upper limit. No significant change of pancreatic enzyme level was noted as a result of hemodialysis, but a significant amount of amylase was removed from the circulation in patients receiving intermittent peritoneal dialysis. Significantly lower pancreatic enzyme levels were observed in patients with less impairment of renal function. We conclude that elevation of pancreatic enzymes in uremic patients is more frequent and more extensive than most articles indicate, and that the extent of increase is related more to renal function than to the modalities of dialysis the patients received.
AB - One hundred thirty blood samples from 87 patients with renal failure, but without abdominal pain, were analyzed for blood urea nitrogen (BUN), creatinine, amylase, p-isoamylase, and lipase simultaneously. We found that 74, 78, and 80% of the patients had hyperamylasemia, hyperisoamylasemia, and hyperlipasemia. None had amylase higher than five times the upper limit. A few patients (2.3%) had lipase elevated to more than 10 times the upper limit. No significant change of pancreatic enzyme level was noted as a result of hemodialysis, but a significant amount of amylase was removed from the circulation in patients receiving intermittent peritoneal dialysis. Significantly lower pancreatic enzyme levels were observed in patients with less impairment of renal function. We conclude that elevation of pancreatic enzymes in uremic patients is more frequent and more extensive than most articles indicate, and that the extent of increase is related more to renal function than to the modalities of dialysis the patients received.
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U2 - 10.1016/0009-9120(88)90009-4
DO - 10.1016/0009-9120(88)90009-4
M3 - Article
C2 - 2455611
AN - SCOPUS:0023772250
SN - 0009-9120
VL - 21
SP - 189
EP - 192
JO - Clinical Biochemistry
JF - Clinical Biochemistry
IS - 3
ER -