Papillary urothelial hyperplasia is a clonal precursor to papillary transitional cell bladder cancer

Nan-Haw Chow, Paul Cairns, Claus F. Eisenberger, Mark P. Schoenberg, David C. Taylor, Jonathan I. Epstein, David Sidransky

Research output: Contribution to journalArticle

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Abstract

Papilloma and papillary hyperplasia (PH) have been proposed to be the putative precursor lesions of papillary transitional-cell carcinoma of the urinary bladder. We examined 15 PH lesions and 4 papillomas for loss of heterozygosity (LOH) at 17 microsatellite markers on 9 chromosomal arms. Eight of 15 (53%) PHs were clonal, demonstrating LOH of at least 1 microsatellite marker. In contrast, none of the papillomas showed any genetic changes among the markers tested. In PH, chromosomal arm 9q was the most frequently lost (4/15), followed by 9p and 18q (n = 2) and, less frequently, 8p, 10q, 11p and 17p (n = 1). Furthermore, 2 hyperplastic lesions demonstrated LOH at 9q only, confirming the notion that allelic loss on chromosomal arm 9q is among the earliest events in bladder-cancer progression. In 1 patient, identical LOH patterns were observed between PH and a recurrent transitional-cell carcinoma. Our molecular data demonstrate that at least a proportion of PHs represent pre-cancerous lesions of the bladder that subsequently progress to papillary bladder cancer. Moreover, chromosomal arm 9q may harbor a tumor-suppressor gene(s) inactivated in the earliest stages of human bladder tumorigenesis. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)514-518
Number of pages5
JournalInternational Journal of Cancer
Volume89
Issue number6
DOIs
Publication statusPublished - 2000 Nov 20

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Loss of Heterozygosity
Urinary Bladder Neoplasms
Hyperplasia
Papilloma
Urinary Bladder
Transitional Cell Carcinoma
Microsatellite Repeats
Papillary Carcinoma
Tumor Suppressor Genes
Carcinogenesis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Chow, Nan-Haw ; Cairns, Paul ; Eisenberger, Claus F. ; Schoenberg, Mark P. ; Taylor, David C. ; Epstein, Jonathan I. ; Sidransky, David. / Papillary urothelial hyperplasia is a clonal precursor to papillary transitional cell bladder cancer. In: International Journal of Cancer. 2000 ; Vol. 89, No. 6. pp. 514-518.
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Papillary urothelial hyperplasia is a clonal precursor to papillary transitional cell bladder cancer. / Chow, Nan-Haw; Cairns, Paul; Eisenberger, Claus F.; Schoenberg, Mark P.; Taylor, David C.; Epstein, Jonathan I.; Sidransky, David.

In: International Journal of Cancer, Vol. 89, No. 6, 20.11.2000, p. 514-518.

Research output: Contribution to journalArticle

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