Pathological changes of human ligament after complete mechanical unloading

Chia Hsin Chen, Xuhui Liu, Ming-Long Yeh, Mao Hsiung Huang, Qihui Zhai, Walter R. Lowe, David M. Lintner, Zong Ping Luo

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

OBJECTIVE: To investigate the pathologic changes with a time sequence among patients with injured ligaments after complete mechanical unloading, based on a human anterior cruciate ligament (ACL) model. DESIGN: Pathologic examinations were done on remnants of completely ruptured ACLs at various times up to 14 wks after injury on 31 patients and on normal ACLs from five cadaver donors. Testing variables included fibroblast density, crimp amplitude, and crimp nuclear shape. RESULTS: Sequential changes were observed: Fibroblast density significantly increased within 5-6 wks of unloading. By 7-8 wks, crimp amplitude significantly decreased, accompanied by formation of irregular fiber patterns and fragments. This was followed by crimp wavelength and nuclear shape change within 9-14 wks. CONCLUSIONS: These pathologic findings suggest that the ACL undergoes significantly deleterious changes from 5 to 6 wks after mechanical unloading. This study may emphasize the important concept of early implementation of mechanical force in rehabilitation programs for patients with injured ligaments.

Original languageEnglish
Pages (from-to)282-289
Number of pages8
JournalAmerican Journal of Physical Medicine and Rehabilitation
Volume86
Issue number4
DOIs
Publication statusPublished - 2007 Apr 1

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Ligaments
Anterior Cruciate Ligament
Fibroblasts
Cadaver
Rehabilitation
Tissue Donors
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation

Cite this

Chen, Chia Hsin ; Liu, Xuhui ; Yeh, Ming-Long ; Huang, Mao Hsiung ; Zhai, Qihui ; Lowe, Walter R. ; Lintner, David M. ; Luo, Zong Ping. / Pathological changes of human ligament after complete mechanical unloading. In: American Journal of Physical Medicine and Rehabilitation. 2007 ; Vol. 86, No. 4. pp. 282-289.
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Pathological changes of human ligament after complete mechanical unloading. / Chen, Chia Hsin; Liu, Xuhui; Yeh, Ming-Long; Huang, Mao Hsiung; Zhai, Qihui; Lowe, Walter R.; Lintner, David M.; Luo, Zong Ping.

In: American Journal of Physical Medicine and Rehabilitation, Vol. 86, No. 4, 01.04.2007, p. 282-289.

Research output: Contribution to journalArticle

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