Pathological functions of hypoxia in endometriosis

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Endometriosis is one of the most common gynecological diseases that significantly reduce the life quality of affected women. Research results from the past decade clearly demonstrated that aberrant production of estrogen and cyclooxygenase-2-derived prostaglandin E2 play indispensable roles in the pathogenesis of this disease. However, the etiology of endometriosis remains obscure. Recent evidence reveals a new facet of endometriotic pathogenesis by showing that hypoxia induces the expression of many important downstream genes to regulate the implantation, survival, and maintenance of ectopic endometriotic lesions. These new findings shed lights on future investigations of delineating the etiology of endometriosis and designing new therapeutic strategy for endometriosis.

Original languageEnglish
Pages (from-to)309-321
Number of pages13
JournalFrontiers in bioscience (Elite edition)
Volume7
Publication statusPublished - 2015 Jan 1

Fingerprint

Endometriosis
Cyclooxygenase 2
Dinoprostone
Estrogens
Genes
Maintenance
Quality of Life
Light
Survival
Hypoxia
Research
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

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Pathological functions of hypoxia in endometriosis. / Hsiao, Kuei Yang; Lin, Shih-Chieh; Wu, Meng-Hsing; Tsai, Shaw-Jenq.

In: Frontiers in bioscience (Elite edition), Vol. 7, 01.01.2015, p. 309-321.

Research output: Contribution to journalReview article

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