Patients with neurogenic lower urinary tract dysfunction following spinal cord injury are at increased risk of developing type 2 diabetes mellitus

A population-based cohort study

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

To investigate whether patients with neurogenic lower urinary tract dysfunction (NLUTD) following spinal cord injury (SCI) are at increased risk of developing type 2 diabetes mellitus (T2DM). The retrospective cohort study used a subset of the Taiwan National Health Insurance Research Database (NHIRD) comprising information on 2 million beneficiaries randomly sampled from the general population. A total of 3515 patients with newly diagnosed SCI were identified during the period of 2001 to 2008. Among them, 170 developed NLUTD following SCI. The control group was consisted of 656 patients without NLUTD over the study period randomly selected by matching NLUTD cases on the date of NLUTD incidence, age, sex, and duration since diagnosis of SCI. The study groups were then followed to the end of 2009. T2DM was the end-point. The incidence rate ratios of T2DM were higher in the NLUTD group than in the control group (4.94 vs. 2.61 per 10,000 person-years), representing an adjusted hazard ratio (AHR) of 1.70 (95% confidence interval [CI] 1.11-2.61). Age-specific AHR was significantly elevated only in patients aged > = 60 years (AHR = 2.52 (95% CI 1.35-4.70)). This study showed that the NLUTD following SCI may significantly increase the risk of developing T2DM.

Original languageEnglish
Article numbere2518
JournalMedicine (United States)
Volume95
Issue number2
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

Urinary Tract
Spinal Cord Injuries
Type 2 Diabetes Mellitus
Cohort Studies
Population
Confidence Intervals
Control Groups
Incidence
National Health Programs
Taiwan
Retrospective Studies
Databases
Research

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{f4af92ed365a4d0bbc958cc7ebffc59b,
title = "Patients with neurogenic lower urinary tract dysfunction following spinal cord injury are at increased risk of developing type 2 diabetes mellitus: A population-based cohort study",
abstract = "To investigate whether patients with neurogenic lower urinary tract dysfunction (NLUTD) following spinal cord injury (SCI) are at increased risk of developing type 2 diabetes mellitus (T2DM). The retrospective cohort study used a subset of the Taiwan National Health Insurance Research Database (NHIRD) comprising information on 2 million beneficiaries randomly sampled from the general population. A total of 3515 patients with newly diagnosed SCI were identified during the period of 2001 to 2008. Among them, 170 developed NLUTD following SCI. The control group was consisted of 656 patients without NLUTD over the study period randomly selected by matching NLUTD cases on the date of NLUTD incidence, age, sex, and duration since diagnosis of SCI. The study groups were then followed to the end of 2009. T2DM was the end-point. The incidence rate ratios of T2DM were higher in the NLUTD group than in the control group (4.94 vs. 2.61 per 10,000 person-years), representing an adjusted hazard ratio (AHR) of 1.70 (95{\%} confidence interval [CI] 1.11-2.61). Age-specific AHR was significantly elevated only in patients aged > = 60 years (AHR = 2.52 (95{\%} CI 1.35-4.70)). This study showed that the NLUTD following SCI may significantly increase the risk of developing T2DM.",
author = "Wei-Chih Lien and Da-Shen Kuan and Yu-Ching Lin and Liang, {Fu Wen} and Pei-Chun Hsieh and Chung-Yi Li",
year = "2016",
month = "1",
day = "1",
doi = "10.1097/MD.0000000000002518",
language = "English",
volume = "95",
journal = "Medicine (United States)",
issn = "0025-7974",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Patients with neurogenic lower urinary tract dysfunction following spinal cord injury are at increased risk of developing type 2 diabetes mellitus

T2 - A population-based cohort study

AU - Lien, Wei-Chih

AU - Kuan, Da-Shen

AU - Lin, Yu-Ching

AU - Liang, Fu Wen

AU - Hsieh, Pei-Chun

AU - Li, Chung-Yi

PY - 2016/1/1

Y1 - 2016/1/1

N2 - To investigate whether patients with neurogenic lower urinary tract dysfunction (NLUTD) following spinal cord injury (SCI) are at increased risk of developing type 2 diabetes mellitus (T2DM). The retrospective cohort study used a subset of the Taiwan National Health Insurance Research Database (NHIRD) comprising information on 2 million beneficiaries randomly sampled from the general population. A total of 3515 patients with newly diagnosed SCI were identified during the period of 2001 to 2008. Among them, 170 developed NLUTD following SCI. The control group was consisted of 656 patients without NLUTD over the study period randomly selected by matching NLUTD cases on the date of NLUTD incidence, age, sex, and duration since diagnosis of SCI. The study groups were then followed to the end of 2009. T2DM was the end-point. The incidence rate ratios of T2DM were higher in the NLUTD group than in the control group (4.94 vs. 2.61 per 10,000 person-years), representing an adjusted hazard ratio (AHR) of 1.70 (95% confidence interval [CI] 1.11-2.61). Age-specific AHR was significantly elevated only in patients aged > = 60 years (AHR = 2.52 (95% CI 1.35-4.70)). This study showed that the NLUTD following SCI may significantly increase the risk of developing T2DM.

AB - To investigate whether patients with neurogenic lower urinary tract dysfunction (NLUTD) following spinal cord injury (SCI) are at increased risk of developing type 2 diabetes mellitus (T2DM). The retrospective cohort study used a subset of the Taiwan National Health Insurance Research Database (NHIRD) comprising information on 2 million beneficiaries randomly sampled from the general population. A total of 3515 patients with newly diagnosed SCI were identified during the period of 2001 to 2008. Among them, 170 developed NLUTD following SCI. The control group was consisted of 656 patients without NLUTD over the study period randomly selected by matching NLUTD cases on the date of NLUTD incidence, age, sex, and duration since diagnosis of SCI. The study groups were then followed to the end of 2009. T2DM was the end-point. The incidence rate ratios of T2DM were higher in the NLUTD group than in the control group (4.94 vs. 2.61 per 10,000 person-years), representing an adjusted hazard ratio (AHR) of 1.70 (95% confidence interval [CI] 1.11-2.61). Age-specific AHR was significantly elevated only in patients aged > = 60 years (AHR = 2.52 (95% CI 1.35-4.70)). This study showed that the NLUTD following SCI may significantly increase the risk of developing T2DM.

UR - http://www.scopus.com/inward/record.url?scp=84958160222&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84958160222&partnerID=8YFLogxK

U2 - 10.1097/MD.0000000000002518

DO - 10.1097/MD.0000000000002518

M3 - Article

VL - 95

JO - Medicine (United States)

JF - Medicine (United States)

SN - 0025-7974

IS - 2

M1 - e2518

ER -