Penile verrucous carcinoma successfully treated by intra-aortic infusion with methotrexate

Maw Chang Sheen, Hamm Ming Sheu, Chun Hsiung Huang, Yi Wen Wang, Chee Yin Chai, Chih Fung Wu

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


Objectives. Penile verrucous carcinoma is characterized by aggressive local growth and a low metastatic potential. Lower abdominal aortic infusion chemotherapy has the main advantage of delivering a very high concentration of an anticancer drug to the whole pelvic area, including the penis, and is especially suitable to treat penile verrucous carcinoma. Methods. From 1991 to 2000, 4 cases of penile verrucous carcinoma were treated by continuous intra-aortic infusion with methotrexate (50 mg) every 24 hours, for an average of 10 days. Citrovorum factor (6 mg) was given intramuscularly every 6 hours during the period of methotrexate infusion. Results. After treatment, 3 patients achieved complete remission. They were living disease free 10 years, 10 months, 6 years, 9 months, and 1 year, 8 months after therapy. Conclusions. Intra-aortic infusion chemotherapy is a simple and effective method for penile verrucous carcinoma with the unique advantage of preserving cosmetic and functional integrity. It may be considered an effective alternative treatment for penile verrucous carcinoma. By using this simple method many unnecessary penectomies can be avoided.

Original languageEnglish
Pages (from-to)1216-1220
Number of pages5
Issue number6
Publication statusPublished - 2003 Jun 1

All Science Journal Classification (ASJC) codes

  • Urology


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