TY - JOUR
T1 - Peripheral inflammation is associated with dysfunctional corticostriatal circuitry and executive dysfunction in bipolar disorder patients
AU - Tseng, Huai Hsuan
AU - Chang, Hui Hua
AU - Wei, Shyh Yuh
AU - Lu, Tsung Hua
AU - Hsieh, Yi Ting
AU - Yang, Yen Kuang
AU - Chen, Po See
N1 - Funding Information:
This work was supported by the Ministry of Science and Technology, Taiwan (MOST 106-2320-B-006-040, MOST 107-2320-B-006-071, MOST 107-2628-B-006-005-, MOST 108-2320-B-006-047-MY3, MOST 108-2314-B-006-045, MOST 108-2320-B-006-004-, MOST 108-2321-B-006-026-MY2, MOST 108-2628-B-006-004-, and MOST 109-2628-B-006-004-) and National Cheng Kung University Hospital (NCKUH-10902014). The authors declare that they have no conflicts of interest in relation to this work. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors are indebted to the research participants. The authors wish to thank Chien Ting Lin for his administrative support. We thank the Mind Research and Imaging Center (MRIC) at National Cheng Kung University for consultation and instrument availability. The MRIC is supported by the Ministry of Science and Technology, Taiwan.
Funding Information:
This work was supported by the Ministry of Science and Technology, Taiwan (MOST 106-2320-B-006-040, MOST 107-2320-B-006-071, MOST 107-2628-B-006-005-, MOST 108-2320-B-006-047-MY3, MOST 108-2314-B-006-045, MOST 108-2320-B-006-004-, MOST 108-2321-B-006-026-MY2, MOST 108-2628-B-006-004-, and MOST 109-2628-B-006-004-) and National Cheng Kung University Hospital (NCKUH-10902014). The authors declare that they have no conflicts of interest in relation to this work. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors are indebted to the research participants. The authors wish to thank Chien Ting Lin for his administrative support. We thank the Mind Research and Imaging Center (MRIC) at National Cheng Kung University for consultation and instrument availability. The MRIC is supported by the Ministry of Science and Technology, Taiwan.
Publisher Copyright:
© 2020
PY - 2021/1
Y1 - 2021/1
N2 - Bipolar disorder (BD) has been linked to abnormal frontal and striatal function, and elevated inflammatory responses. However, the impact of peripheral inflammation on the corticostriatal functional connectivity (FC) remains obscure in BD. The current study aimed to explore the association between peripheral inflammation and corticostriatal connectivity in euthymic BD. We recruited 25 euthymic BD patients and 43 healthy controls (HCs) from the community. Resting state functional images were obtained using 3T magnetic resonance imaging (fMRI), and striatal seed-based whole-brain functional connectivity analyses were performed, with the fasting plasma high-sensitivity C-reactive protein (hs-CRP) level entered as a regressor of interest. The participants also completed the Wisconsin Card-Sorting Test (WCST) and the Continuous Performance Test (CPT). The euthymic BD group had a similar hs-CRP level to the HC group, but a significantly poorer cognitive performance. Compared with the HC group, a higher connectivity between the right dorsal caudal putamen (dcP) and the ventral lateral prefrontal cortex (vlPFC) in the BD group was significantly correlated with a higher hs-CRP level. Stronger dcP-vlPFC connectivity was correlated with a lower CPT unmasked d' in the BD group. BD patients might be particularly sensitive to the effects of inflammation on corticostriatal connectivity. The potentially greater sensitivity of BD patients to peripheral inflammation may differentially modulate the cognitive and reward related corticostriatal circuitry, which may contribute to the pathophysiology of cognitive-affective dysregulation in the euthymic state. Anti-inflammatory or other circuit-specific treatment is warranted for individualized treatment in BD.
AB - Bipolar disorder (BD) has been linked to abnormal frontal and striatal function, and elevated inflammatory responses. However, the impact of peripheral inflammation on the corticostriatal functional connectivity (FC) remains obscure in BD. The current study aimed to explore the association between peripheral inflammation and corticostriatal connectivity in euthymic BD. We recruited 25 euthymic BD patients and 43 healthy controls (HCs) from the community. Resting state functional images were obtained using 3T magnetic resonance imaging (fMRI), and striatal seed-based whole-brain functional connectivity analyses were performed, with the fasting plasma high-sensitivity C-reactive protein (hs-CRP) level entered as a regressor of interest. The participants also completed the Wisconsin Card-Sorting Test (WCST) and the Continuous Performance Test (CPT). The euthymic BD group had a similar hs-CRP level to the HC group, but a significantly poorer cognitive performance. Compared with the HC group, a higher connectivity between the right dorsal caudal putamen (dcP) and the ventral lateral prefrontal cortex (vlPFC) in the BD group was significantly correlated with a higher hs-CRP level. Stronger dcP-vlPFC connectivity was correlated with a lower CPT unmasked d' in the BD group. BD patients might be particularly sensitive to the effects of inflammation on corticostriatal connectivity. The potentially greater sensitivity of BD patients to peripheral inflammation may differentially modulate the cognitive and reward related corticostriatal circuitry, which may contribute to the pathophysiology of cognitive-affective dysregulation in the euthymic state. Anti-inflammatory or other circuit-specific treatment is warranted for individualized treatment in BD.
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U2 - 10.1016/j.bbi.2020.09.010
DO - 10.1016/j.bbi.2020.09.010
M3 - Article
C2 - 32950621
AN - SCOPUS:85091498122
SN - 0889-1591
VL - 91
SP - 695
EP - 702
JO - Brain, Behavior, and Immunity
JF - Brain, Behavior, and Immunity
ER -