PH-responsive magnetic micelles gelatin-: G-poly(NIPAAm-co-DMAAm-co-UA)-g-dextran/Fe3O4 as a hydrophilic drug carrier

Chao Ming Su, Chen Yu Huang, Yao Li Chen, Tzong Rong Ger

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

pH-responsive magnetic micelles are beneficial for time-controlled and site-specific drug delivery without triggering potential biological side effects. In this study, gelatin-g-poly(NIPAAm-co-DMAAm-co-UA)-g-dextran/Fe3O4 (GPDF) pH-responsive magnetic micelles were synthesized to carry a hydrophilic insulin-promoting factor, nicotinamide. The chemical structures were analyzed via Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR) spectroscopy. Superconducting quantum interference device (SQUID) analysis confirmed the superparamagnetic property of the GPDF micelle. The accumulative nicotinamide release under pathological pH conditions (pH 6.6) was found to be three-fold higher than that under normal pH conditions (pH 7.2). The results suggest that GPDF is beneficial for a pH-selective and magnetic target-controlled release drug delivery system.

Original languageEnglish
Pages (from-to)28207-28212
Number of pages6
JournalRSC Advances
Volume7
Issue number45
DOIs
Publication statusPublished - 2017 Jan 1

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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