PH-responsive magnetic micelles gelatin-: G-poly(NIPAAm-co-DMAAm-co-UA)-g-dextran/Fe3O4 as a hydrophilic drug carrier

Chao Ming Su; Chen Yu Huang; Yao Li Chen; Tzong Rong Ger

doi:10.1039/c7ra01633f

PH-responsive magnetic micelles gelatin-: G-poly(NIPAAm-co-DMAAm-co-UA)-g-dextran/Fe₃O₄ as a hydrophilic drug carrier

Chao Ming Su, Chen Yu Huang, Yao Li Chen, Tzong Rong Ger

Department of Medical Laboratory Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

pH-responsive magnetic micelles are beneficial for time-controlled and site-specific drug delivery without triggering potential biological side effects. In this study, gelatin-g-poly(NIPAAm-co-DMAAm-co-UA)-g-dextran/Fe₃O₄ (GPDF) pH-responsive magnetic micelles were synthesized to carry a hydrophilic insulin-promoting factor, nicotinamide. The chemical structures were analyzed via Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR) spectroscopy. Superconducting quantum interference device (SQUID) analysis confirmed the superparamagnetic property of the GPDF micelle. The accumulative nicotinamide release under pathological pH conditions (pH 6.6) was found to be three-fold higher than that under normal pH conditions (pH 7.2). The results suggest that GPDF is beneficial for a pH-selective and magnetic target-controlled release drug delivery system.

Original language	English
Pages (from-to)	28207-28212
Number of pages	6
Journal	RSC Advances
Volume	7
Issue number	45
DOIs	https://doi.org/10.1039/c7ra01633f
Publication status	Published - 2017 Jan 1

All Science Journal Classification (ASJC) codes

General Chemistry
General Chemical Engineering

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abstract = "pH-responsive magnetic micelles are beneficial for time-controlled and site-specific drug delivery without triggering potential biological side effects. In this study, gelatin-g-poly(NIPAAm-co-DMAAm-co-UA)-g-dextran/Fe3O4 (GPDF) pH-responsive magnetic micelles were synthesized to carry a hydrophilic insulin-promoting factor, nicotinamide. The chemical structures were analyzed via Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR) spectroscopy. Superconducting quantum interference device (SQUID) analysis confirmed the superparamagnetic property of the GPDF micelle. The accumulative nicotinamide release under pathological pH conditions (pH 6.6) was found to be three-fold higher than that under normal pH conditions (pH 7.2). The results suggest that GPDF is beneficial for a pH-selective and magnetic target-controlled release drug delivery system.",

author = "Su, {Chao Ming} and Huang, {Chen Yu} and Chen, {Yao Li} and Ger, {Tzong Rong}",

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PH-responsive magnetic micelles gelatin-: G-poly(NIPAAm-co-DMAAm-co-UA)-g-dextran/Fe₃O₄ as a hydrophilic drug carrier

Abstract

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