Phenanthroindolizidine alkaloids and their cytotoxicity from the leaves of Ficus septica

Pei Lin Wu, K. V. Rao, Chia Hao Su, Cheng Sheng Kuoh, Tian Shung Wu

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49 Citations (Scopus)

Abstract

Phenanthroindolizidine N-Oxide, ficuseptine-A (1), together with eighteen known compounds was isolated from the leaves of Ficus septica. The structures of these compounds were elucidated by spectroscopic analysis. Among them, phenanthroindolizidines, ficuseptine (1), (+)-tylophorine (4) and a mixture of (+)-tylocrebrine (5) and (+)-isotylocrebrine (6), exhibited strong cytotoxic activity against two human cancer cell lines, NUGC and HONE-1.

Original languageEnglish
Pages (from-to)2401-2408
Number of pages8
JournalHeterocycles
Volume57
Issue number12
DOIs
Publication statusPublished - 2002 Dec 1

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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  • Cite this

    Wu, P. L., Rao, K. V., Su, C. H., Kuoh, C. S., & Wu, T. S. (2002). Phenanthroindolizidine alkaloids and their cytotoxicity from the leaves of Ficus septica. Heterocycles, 57(12), 2401-2408. https://doi.org/10.3987/COM-02-9615