Photoacoustic imaging of multiple targets using gold nanorods

Pai Chi Li, Chen Wei Wei, Chao Kang Liao, Cheng Dah Chen, Kuei Chen Pao, Churng Ren Chris Wang, Ya Na Wu, Dar Bin Shieh

Research output: Contribution to journalArticlepeer-review

104 Citations (Scopus)

Abstract

Photoacoustlc (PA) Imaging has been used mainly for anatomical and functional imaging. Although functionalized nanoparticles also have been developed for PA molecular Imaging, only single targeting has been demonstrated. In this study, PA Imaging of multiple targets using gold nanorods is demonstrated experimentally using HER2 and CXCR4 as target molecules. The two corresponding monoclonal antibodies were conjugated to two types of gold nanorod with different aspect ratios. Gold nanorods with mean aspect ratios of 5.9 and 3.7 exhibited peak optical absorptions at 1000 and 785 nm, respectively. Appropriate selection of laser irradiation wavelength enhances PA signals by 7-12 dB and allows signals from gold nanorods corresponding to specific bindings to be distinguished. This approach potentially allows the expression levels of different oncogenes of cancer cells to be revealed simultaneously.

Original languageEnglish
Pages (from-to)1642-1647
Number of pages6
JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Volume54
Issue number8
DOIs
Publication statusPublished - 2007 Aug 1

All Science Journal Classification (ASJC) codes

  • Instrumentation
  • Acoustics and Ultrasonics
  • Electrical and Electronic Engineering

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