Photocontrolled targeted drug delivery: Photocaged biologically active folic acid as a light-responsive tumor-targeting molecule

Nien Chu Fan, Fong Yu Cheng, Ja An Annie Ho, Chen Sheng Yeh

Research output: Contribution to journalArticlepeer-review

140 Citations (Scopus)

Abstract

Light-controlled: Biodegradable nanoparticles encapsulating an anticancer drug (red dots in picture) have been synthesized that carry photocaged folate groups on the surface. Upon irradiation the photocaging group (green) is removed and the free folate group, a tumor-homing agent, binds to folate receptors on cell surfaces, thus leading to specific targeting and cellular uptake.

Original languageEnglish
Pages (from-to)8806-8810
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number35
DOIs
Publication statusPublished - 2012 Aug 27

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Photocontrolled targeted drug delivery: Photocaged biologically active folic acid as a light-responsive tumor-targeting molecule'. Together they form a unique fingerprint.

Cite this