Phthalates metabolite levels as effective predictors for childhood allergic responses and reporting respiratory symptoms

Nai Yun Hsu, Ching Chang Lee, Yi Cheng Li, Hsin Wen Chang, Jiu Yao Wang, Chung Yu Chen, Carl Gustaf Bornehag, Pei Chih Wu, Jan Sundell, Huey Jen Su

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The aim of this study was to characterize the association between phthalates exposure, through the representative biomarker, and childhood allergic and respiratory morbidity after adjusting for exposure to common indoor pollutants, especially bioaerosols. A total of 101 children were examined for their urinary metabolites of phthalates and indoor chemical or biological exposure. Children with higher urinary levels of phthalates are more likely to be categorized as "case" (aOR of MBzP=1.81, 95%CI=0.97-3.37), reporting higher frequency of parental reporting symptoms (aOR of MBzP=2.12, 95%CI=1.15-3.91), being found sensitized to inhalant (aOR of MBP=3.60, 95%CI=1.14-11.40) or mite allergens (aOR of MBP=2.48, 95%CI=1.34-4.62), and to present higher severity of physician-diagnosed diseases during clinic visits (β of MEHP=0.20, p=0.07). Moreover, I/O ratios of culturable fungi and endotoxin were also suggested as significant risks. The relative contribution from phthalates and indoor-originated bio-contaminants exposure on childhood allergic and respiratory morbidities is for the first time quantitatively characterized.

Original languageEnglish
Title of host publication12th International Conference on Indoor Air Quality and Climate 2011
Pages157-162
Number of pages6
Publication statusPublished - 2011 Dec 1
Event12th International Conference on Indoor Air Quality and Climate 2011 - Austin, TX, United States
Duration: 2011 Jun 52011 Jun 10

Publication series

Name12th International Conference on Indoor Air Quality and Climate 2011
Volume1

Other

Other12th International Conference on Indoor Air Quality and Climate 2011
CountryUnited States
CityAustin, TX
Period11-06-0511-06-10

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All Science Journal Classification (ASJC) codes

  • Pollution

Cite this

Hsu, N. Y., Lee, C. C., Li, Y. C., Chang, H. W., Wang, J. Y., Chen, C. Y., Bornehag, C. G., Wu, P. C., Sundell, J., & Su, H. J. (2011). Phthalates metabolite levels as effective predictors for childhood allergic responses and reporting respiratory symptoms. In 12th International Conference on Indoor Air Quality and Climate 2011 (pp. 157-162). (12th International Conference on Indoor Air Quality and Climate 2011; Vol. 1).