Abstract
A novel withasteroid, physanolide A (1), with an unprecedented skeleton containing a seven-membered ring, and two new physalins, physalins U (2) and V (3), were isolated from Physalis angulata. The structures were elucidated from spectroscopic analysis, and plausible biosynthetic pathways were postulated. Physalins B (4), D (5), and F (6) showed strong cytotoxicity against multiple tumor cell lines, including KB, A431, HCT-8, PC-3, and ZR751, with EC 50 values less than 4 μg/mL
Original language | English |
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Pages (from-to) | 2953-2956 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 8 |
Issue number | 14 |
DOIs | |
Publication status | Published - 2006 Jul 6 |
All Science Journal Classification (ASJC) codes
- Molecular Medicine