Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata

Ping-Chung Kuo; Tsung Hsiao Kuo; Amooru G. Damu; Chung Ren Su; E-Jian Lee; Tian-Shung Wu; Rexen Shu; Chou Ming Chen; Kenneth F. Bastow; Tzu Hsuan Chen; Kuo Hsiung Lee

doi:10.1021/ol060801s

Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata

Ping-Chung Kuo, Tsung Hsiao Kuo, Amooru G. Damu, Chung Ren Su, E-Jian Lee, Tian-Shung Wu, Rexen Shu, Chou Ming Chen, Kenneth F. Bastow, Tzu Hsuan Chen, Kuo Hsiung Lee

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Abstract

A novel withasteroid, physanolide A (1), with an unprecedented skeleton containing a seven-membered ring, and two new physalins, physalins U (2) and V (3), were isolated from Physalis angulata. The structures were elucidated from spectroscopic analysis, and plausible biosynthetic pathways were postulated. Physalins B (4), D (5), and F (6) showed strong cytotoxicity against multiple tumor cell lines, including KB, A431, HCT-8, PC-3, and ZR751, with EC ₅₀ values less than 4 μg/mL

Original language	English
Pages (from-to)	2953-2956
Number of pages	4
Journal	Organic Letters
Volume	8
Issue number	14
DOIs	https://doi.org/10.1021/ol060801s
Publication status	Published - 2006 Jul 6

All Science Journal Classification (ASJC) codes

Molecular Medicine

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10.1021/ol060801s

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title = "Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata",

abstract = "A novel withasteroid, physanolide A (1), with an unprecedented skeleton containing a seven-membered ring, and two new physalins, physalins U (2) and V (3), were isolated from Physalis angulata. The structures were elucidated from spectroscopic analysis, and plausible biosynthetic pathways were postulated. Physalins B (4), D (5), and F (6) showed strong cytotoxicity against multiple tumor cell lines, including KB, A431, HCT-8, PC-3, and ZR751, with EC 50 values less than 4 μg/mL",

author = "Ping-Chung Kuo and Kuo, {Tsung Hsiao} and Damu, {Amooru G.} and Su, {Chung Ren} and E-Jian Lee and Tian-Shung Wu and Rexen Shu and Chen, {Chou Ming} and Bastow, {Kenneth F.} and Chen, {Tzu Hsuan} and Lee, {Kuo Hsiung}",

year = "2006",

month = jul,

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doi = "10.1021/ol060801s",

language = "English",

volume = "8",

pages = "2953--2956",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "14",

}

Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata. / Kuo, Ping-Chung; Kuo, Tsung Hsiao; Damu, Amooru G.; Su, Chung Ren; Lee, E-Jian; Wu, Tian-Shung; Shu, Rexen; Chen, Chou Ming; Bastow, Kenneth F.; Chen, Tzu Hsuan; Lee, Kuo Hsiung.

In: Organic Letters, Vol. 8, No. 14, 06.07.2006, p. 2953-2956.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata

AU - Kuo, Ping-Chung

AU - Kuo, Tsung Hsiao

AU - Damu, Amooru G.

AU - Su, Chung Ren

AU - Lee, E-Jian

AU - Wu, Tian-Shung

AU - Shu, Rexen

AU - Chen, Chou Ming

AU - Bastow, Kenneth F.

AU - Chen, Tzu Hsuan

AU - Lee, Kuo Hsiung

PY - 2006/7/6

Y1 - 2006/7/6

N2 - A novel withasteroid, physanolide A (1), with an unprecedented skeleton containing a seven-membered ring, and two new physalins, physalins U (2) and V (3), were isolated from Physalis angulata. The structures were elucidated from spectroscopic analysis, and plausible biosynthetic pathways were postulated. Physalins B (4), D (5), and F (6) showed strong cytotoxicity against multiple tumor cell lines, including KB, A431, HCT-8, PC-3, and ZR751, with EC 50 values less than 4 μg/mL

AB - A novel withasteroid, physanolide A (1), with an unprecedented skeleton containing a seven-membered ring, and two new physalins, physalins U (2) and V (3), were isolated from Physalis angulata. The structures were elucidated from spectroscopic analysis, and plausible biosynthetic pathways were postulated. Physalins B (4), D (5), and F (6) showed strong cytotoxicity against multiple tumor cell lines, including KB, A431, HCT-8, PC-3, and ZR751, with EC 50 values less than 4 μg/mL

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JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 14

ER -

Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata

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All Science Journal Classification (ASJC) codes

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