Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata

Ping-Chung Kuo, Tsung Hsiao Kuo, Amooru G. Damu, Chung Ren Su, E-Jian Lee, Tian-Shung Wu, Rexen Shu, Chou Ming Chen, Kenneth F. Bastow, Tzu Hsuan Chen, Kuo Hsiung Lee

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)

Abstract

A novel withasteroid, physanolide A (1), with an unprecedented skeleton containing a seven-membered ring, and two new physalins, physalins U (2) and V (3), were isolated from Physalis angulata. The structures were elucidated from spectroscopic analysis, and plausible biosynthetic pathways were postulated. Physalins B (4), D (5), and F (6) showed strong cytotoxicity against multiple tumor cell lines, including KB, A431, HCT-8, PC-3, and ZR751, with EC 50 values less than 4 μg/mL

Original languageEnglish
Pages (from-to)2953-2956
Number of pages4
JournalOrganic Letters
Volume8
Issue number14
DOIs
Publication statusPublished - 2006 Jul 6

All Science Journal Classification (ASJC) codes

  • Molecular Medicine

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