Physical processing for decellularized nerve xenograft in peripheral nerve regeneration

Ming Wei Hsu, Szu Han Chen, Wan Ling Tseng, Kuo Shu Hung, Tzu Chun Chung, Sheng Che Lin, Jahyun Koo, Yuan Yu Hsueh

Research output: Contribution to journalShort surveypeer-review

2 Citations (Scopus)

Abstract

In severe or complex cases of peripheral nerve injuries, autologous nerve grafts are the gold standard yielding promising results, but limited availability and donor site morbidity are some of its disadvantages. Although biological or synthetic substitutes are commonly used, clinical outcomes are inconsistent. Biomimetic alternatives derived from allogenic or xenogenic sources offer an attractive off-the-shelf supply, and the key to successful peripheral nerve regeneration focuses on an effective decellularization process. In addition to chemical and enzymatic decellularization protocols, physical processes might offer identical efficiency. In this comprehensive minireview, we summarize recent advances in the physical methods for decellularized nerve xenograft, focusing on the effects of cellular debris clearance and stability of the native architecture of a xenograft. Furthermore, we compare and summarize the advantages and disadvantages, indicating the future challenges and opportunities in developing multidisciplinary processes for decellularized nerve xenograft.

Original languageEnglish
Article number1217067
JournalFrontiers in Bioengineering and Biotechnology
Volume11
DOIs
Publication statusPublished - 2023

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Histology
  • Biomedical Engineering

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