Pineal stimulation produces both hypertension and tachycardia in rats

J. I. Chuang, M. T. Lin

Research output: Contribution to journalArticlepeer-review

Abstract

In anesthetized rats, electrical stimulation of pineal gland elicited proportional hypertension and tachycardia, which could be mimicked by microinjection of an excitatory amino acid, kainic acid (0.3 μg), into the pineal gland. The hypertension induced by pineal stimulation was antagonized by either spinal transection or postsynaptic blockade of serotonin receptors, while the tachycardia induced by pineal stimulation was antagonized by either serotonin receptor antagonism, bilateral vagotomy or spinal transection. In addition, postsynaptic blockade of serotonin receptors with cyproheptadine (2-5 mg/Kg, IV) produced both hypotension and bradycardia, while stimulation of 5-HT receptors with DOI (10-250 μg/Kg, IV) produced both hypertension and tachycardia in rats. The results indicate that pineal stimulation activates brain 5-HT receptors and results in sympathetic stimulation or parasympathetic inhibition which leads to hypertension and tachycardia in rats.

Original languageEnglish
Pages (from-to)473-476
Number of pages4
JournalBrain Research Bulletin
Volume33
Issue number5
DOIs
Publication statusPublished - 1994

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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