TY - JOUR
T1 - Pineal stimulation produces both hypertension and tachycardia in rats
AU - Chuang, J. I.
AU - Lin, M. T.
N1 - Funding Information:
The work reported here was supported by grants from the National Science Council of Republic of China. The authors wish to thank Dr. C. Y. Chai for helpful discussion during experimentation.
PY - 1994
Y1 - 1994
N2 - In anesthetized rats, electrical stimulation of pineal gland elicited proportional hypertension and tachycardia, which could be mimicked by microinjection of an excitatory amino acid, kainic acid (0.3 μg), into the pineal gland. The hypertension induced by pineal stimulation was antagonized by either spinal transection or postsynaptic blockade of serotonin receptors, while the tachycardia induced by pineal stimulation was antagonized by either serotonin receptor antagonism, bilateral vagotomy or spinal transection. In addition, postsynaptic blockade of serotonin receptors with cyproheptadine (2-5 mg/Kg, IV) produced both hypotension and bradycardia, while stimulation of 5-HT receptors with DOI (10-250 μg/Kg, IV) produced both hypertension and tachycardia in rats. The results indicate that pineal stimulation activates brain 5-HT receptors and results in sympathetic stimulation or parasympathetic inhibition which leads to hypertension and tachycardia in rats.
AB - In anesthetized rats, electrical stimulation of pineal gland elicited proportional hypertension and tachycardia, which could be mimicked by microinjection of an excitatory amino acid, kainic acid (0.3 μg), into the pineal gland. The hypertension induced by pineal stimulation was antagonized by either spinal transection or postsynaptic blockade of serotonin receptors, while the tachycardia induced by pineal stimulation was antagonized by either serotonin receptor antagonism, bilateral vagotomy or spinal transection. In addition, postsynaptic blockade of serotonin receptors with cyproheptadine (2-5 mg/Kg, IV) produced both hypotension and bradycardia, while stimulation of 5-HT receptors with DOI (10-250 μg/Kg, IV) produced both hypertension and tachycardia in rats. The results indicate that pineal stimulation activates brain 5-HT receptors and results in sympathetic stimulation or parasympathetic inhibition which leads to hypertension and tachycardia in rats.
UR - https://www.scopus.com/pages/publications/0028222126
UR - https://www.scopus.com/pages/publications/0028222126#tab=citedBy
U2 - 10.1016/0361-9230(94)90070-1
DO - 10.1016/0361-9230(94)90070-1
M3 - Article
C2 - 8186991
AN - SCOPUS:0028222126
SN - 0361-9230
VL - 33
SP - 473
EP - 476
JO - Brain Research Bulletin
JF - Brain Research Bulletin
IS - 5
ER -