TY - JOUR
T1 - Pituitary adenylate cyclase-activating polypeptide prevents cell death in the spinal cord with traumatic injury
AU - Chen, Wen Hsin
AU - Tzeng, Shun Fen
N1 - Funding Information:
The authors thank Ms. Jey-Pei Wu for her skillful technical assistance. The study was supported in part by National Health Research Institutes (NHRI grant NHRI-EX91-8907BC), Taiwan, ROC, and Taichung Veterans General Hospital (TCVGH-917309D), Taiwan, ROC.
PY - 2005/8/12
Y1 - 2005/8/12
N2 - Pituitary adenylyl cyclase-activating polypeptide (PACAP) is a potent factor in the regulation of neurotransmission, neuroprotection, neurogenesis and anti-inflammation. We here examined the neuroprotective effect of PACAP on injury to the spinal cord tissue of adult rats, induced by dropping a 10 g NYU impactor from the height of 25 mm (moderate injury) or 50 mm (severe injury). PACAP was found to effectively attenuate cell apoptosis in the spinal cord with moderate injury. However, treatment with PACAP had a lesser effect on decreasing DNA fragmentation in the lesion center of the spinal cord with severe contusion injury. Yet, greater extended neural fibers and motor neurons were observed in the rostral and caudal regions of the PACAP-treated spinal cord when compared to that seen in the PBS-treated control. Our findings indicate the beneficial effect of PACAP for the treatment of spinal cord injury (SCI).
AB - Pituitary adenylyl cyclase-activating polypeptide (PACAP) is a potent factor in the regulation of neurotransmission, neuroprotection, neurogenesis and anti-inflammation. We here examined the neuroprotective effect of PACAP on injury to the spinal cord tissue of adult rats, induced by dropping a 10 g NYU impactor from the height of 25 mm (moderate injury) or 50 mm (severe injury). PACAP was found to effectively attenuate cell apoptosis in the spinal cord with moderate injury. However, treatment with PACAP had a lesser effect on decreasing DNA fragmentation in the lesion center of the spinal cord with severe contusion injury. Yet, greater extended neural fibers and motor neurons were observed in the rostral and caudal regions of the PACAP-treated spinal cord when compared to that seen in the PBS-treated control. Our findings indicate the beneficial effect of PACAP for the treatment of spinal cord injury (SCI).
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U2 - 10.1016/j.neulet.2005.04.070
DO - 10.1016/j.neulet.2005.04.070
M3 - Article
C2 - 15913892
AN - SCOPUS:20444499677
VL - 384
SP - 117
EP - 121
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1-2
ER -