@inproceedings{63aed83071744a0e8fd0fc837dd0cde3,
title = "Planar patch-clamp chip integrated with microfluidic concentration generator for rapid solution exchange",
abstract = "Planar patch-clamp chips have been developed in varies approaches to simplify ion-channel signal detection. Integration with microfluidics has mainly focused on delivery of prepared solutions to the chip. This work presents the integration of planar patch-clamp chip with microfluidic concentration generator for rapid solution exchange. Different concentrations of fluid could be rapidly delivered and exchanged by adjusting relative flow rate of each inlet, and fully mixed through a micromixer. Endogenous chloride channels in human embryonic kidney 293T cells were successfully examined in various osmolarities generated by the concentration generator. This practical approach demonstrates the potential of integrated microfluidic patch-clamp system for high throughput ion channel screening of drugs.",
author = "Chen, {Chang Yu} and Liu, {Kuan Ting} and Tu, {Ting Yuan} and Jong, {De Shien} and Wo, {Andrew M.}",
year = "2009",
month = jan,
day = "1",
language = "English",
isbn = "9780979806421",
series = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "506--508",
booktitle = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
note = "13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 ; Conference date: 01-11-2009 Through 05-11-2009",
}