Plant-made vaccines against avian reovirus

Ching Chun Chang, Hung Jen Liu

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Viral arthritis, chronic respiratory disease, malabsorption syndrome, hepatitis and myocarditis cause considerable economic losses in the poultry industry and are directly or indirectly linked to avian reovirus (ARV). The outer capsid proteins of the ARV, σC and σB, encoded by the S1 and S3 genome segments, respectively, are the prime candidates for development of a subunit vaccine against ARV infection. To develop a plant-based vaccine for immunizing poultry against ARV infection, transgenic alfalfa, Arabidopsis and tobacco expressing recombinant σC protein have been generated. Transgenic Arabidopsis with the highest expression of σC were used to subcutaneously or orally vaccinate specific-pathogen free (SPF) chickens. The Arabidopsis-expressed recombinant rC protein could induce immune response in chickens and conferred significant protection against viral challenge. Future investigations to improve theσCand/or σB protein levels in edible plants will pave the way for commercially large-scale vaccination against ARVs in the poultry industry.

Original languageEnglish
Title of host publicationProspects of Plant-Based Vaccines in Veterinary Medicine
PublisherSpringer International Publishing
Pages209-223
Number of pages15
ISBN (Electronic)9783319901374
ISBN (Print)9783319901367
DOIs
Publication statusPublished - 2018 Jul 3

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Engineering(all)
  • Agricultural and Biological Sciences(all)
  • Health Professions(all)

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  • Cite this

    Chang, C. C., & Liu, H. J. (2018). Plant-made vaccines against avian reovirus. In Prospects of Plant-Based Vaccines in Veterinary Medicine (pp. 209-223). Springer International Publishing. https://doi.org/10.1007/978-3-319-90137-4_9