Plasma free amino acid profile in cancer patients

Hong Shiee Lai, Jenq Chang Lee, Po Huang Lee, Shan Tair Wang, Wei Jao Chen

Research output: Contribution to journalReview articlepeer-review

140 Citations (Scopus)


Redistribution or translocation of plasma free amino acids (PFAAs) to support visceral or tumor protein synthesis is an essential feature in cancer patients. An abnormal PFAA profile might be presented via the total reflection of cancer-induced protein metabolism in tumors, skeletal muscle and the liver in cancer patients. Clinical data from 13 studies have demonstrated a cancer-related PFAA profile, especially in digestive organ cancers. The PFAA profile can differ between the early and late stages of cancer. The profile is also affected by the type of cancer. Therefore, it is postulated that a detailed analysis of the PFAA profile may serve as one of the biological markers for cancer patients.

Original languageEnglish
Pages (from-to)267-276
Number of pages10
JournalSeminars in Cancer Biology
Issue number4
Publication statusPublished - 2005 Aug

All Science Journal Classification (ASJC) codes

  • Cancer Research


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