Plasma free amino acid profile in cancer patients

Hong Shiee Lai, Jenq-Chang Lee, Po Huang Lee, Shan-Tair Wang, Wei Jao Chen

Research output: Contribution to journalReview article

101 Citations (Scopus)

Abstract

Redistribution or translocation of plasma free amino acids (PFAAs) to support visceral or tumor protein synthesis is an essential feature in cancer patients. An abnormal PFAA profile might be presented via the total reflection of cancer-induced protein metabolism in tumors, skeletal muscle and the liver in cancer patients. Clinical data from 13 studies have demonstrated a cancer-related PFAA profile, especially in digestive organ cancers. The PFAA profile can differ between the early and late stages of cancer. The profile is also affected by the type of cancer. Therefore, it is postulated that a detailed analysis of the PFAA profile may serve as one of the biological markers for cancer patients.

Original languageEnglish
Pages (from-to)267-276
Number of pages10
JournalSeminars in Cancer Biology
Volume15
Issue number4
DOIs
Publication statusPublished - 2005 Aug 1

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Amino Acids
Neoplasms
Liver Neoplasms
Skeletal Muscle
Proteins
Biomarkers

All Science Journal Classification (ASJC) codes

  • Cancer Research

Cite this

Lai, Hong Shiee ; Lee, Jenq-Chang ; Lee, Po Huang ; Wang, Shan-Tair ; Chen, Wei Jao. / Plasma free amino acid profile in cancer patients. In: Seminars in Cancer Biology. 2005 ; Vol. 15, No. 4. pp. 267-276.
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Plasma free amino acid profile in cancer patients. / Lai, Hong Shiee; Lee, Jenq-Chang; Lee, Po Huang; Wang, Shan-Tair; Chen, Wei Jao.

In: Seminars in Cancer Biology, Vol. 15, No. 4, 01.08.2005, p. 267-276.

Research output: Contribution to journalReview article

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