Plasma homocysteine levels in Taiwanese vegetarians are higher than those of omnivores

Chien Jung Hung, Po Chao Huang, Shao Chun Lu, Yi Hwei Li, Hsien Bin Huang, Bi Fong Lin, Sue Joan Chang, Hsu Fang Chou

Research output: Contribution to journalArticlepeer-review

82 Citations (Scopus)


Mild hyperhomocysteinemia is an independent risk factor for cardiovascular disease and may result from a deficiency of folate, vitamin B-6 or vitamin B-12. Because vitamin B-12 deficiency is often associated with vegetarianism, this study was designed to examine the effect of Taiwanese vegetarian diets on B-vitamin status and plasma homocysteine levels. Female Buddhist lacto-vegetarians (n = 45; 31-45 y) and matched omnivores (n = 45) recruited in Hualien, Taiwan, were investigated. Taiwanese vegetarians consumed normal amount of folate, but only 21% of Taiwan Recommended Daily Nutrient Allowances (RDNA) values of vitamin B-12. Compared with the omnivores, the vegetarians had significantly higher levels of plasma folate (14.79 ± 7.70 vs, 11.98 ± 8.29 nmol/L), but lower levels of vitamin B-12 (207.7 ± 127.1 vs. 403.5 ± 138.9 pmol/L). Fasting plasma homocysteine levels were significantly higher in vegetarians than in omnivores (mean: 11.20 ± 4.27 vs. 8.64 ± 2.06 μmol/L; median: 10.5 vs. 8.5 μmol/L). Fasting plasma homocysteine was inversely correlated with plasma folate and vitamin B-12 in the vegetarian group. Multiple regression analysis revealed that plasma folate, vitamin B-12 and creatinine were independent determinants of homocysteine variation and contributed to 38.6% of homocysteine variation in the vegetarians. Compared with the omnivores, vegetarians also had significantly lower serum levels of valine, isoleucine, leucine, lysine, alanine and arginine, but higher levels of glycine. In the vegetarian group, fasting plasma homocysteine correlated negatively with serum threonine, lysine, histidine, arginine and cystine, and these amino acids contributed to 38.7% of homocysteine variation. In conclusion, the Buddhist nuns who consumed a lacto-vegetarian diet had mildly elevated fasting plasma homocysteine levels presumably due to lower levels of plasma vitamin B-12.

Original languageEnglish
Pages (from-to)152-158
Number of pages7
JournalJournal of Nutrition
Issue number2
Publication statusPublished - 2002

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


Dive into the research topics of 'Plasma homocysteine levels in Taiwanese vegetarians are higher than those of omnivores'. Together they form a unique fingerprint.

Cite this