Platelet 5-HT and plasma MHPG levels in patients with bipolar I and bipolar II depressions and normal controls

I. Shin Shiah, Huei Chen Ko, Jia Fu Lee, Ru Band Lu

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Background: It has been suggested that platelet serotonin (5-HT) content may reflect aspects of the presynaptic reuptake of 5-HT, while plasma 3- methoxy-4-hydroxy-phenylglycol (MHPG) levels may provide an index of central noradrenergic function. Methods: In order to determine if there is a biological distinction in 5-HT or noradrenergic function within bipolar I and bipolar II depressions, we measured levels of platelet 5-HT and plasma MHPG in 12 patients with bipolar I depression, 12 patients with bipolar II depression, and 20 normal healthy controls. All subjects were medication free for at least 4 weeks prior to the study. Results: There was a trend towards higher platelet 5-HT in bipolar I or II depressions when compared to normal controls, whereas there was no difference in platelet 5-HT levels between bipolar I and II depressed patients. When bipolar I and II patients were pooled, there was a significant increase in platelet 5-HT levels in bipolar depressives compared to normal controls, and there was a trend towards a weak positive correlation between platelet 5-HT and 21-item HAMD scores in the patient group. In contrast, there was no difference in plasma MHPG levels between the three groups. Limitations: This study was limited to a small sample size, single point sampling and did not match seasons. Conclusions: Our findings did not provide supportive evidence for a distinctive 5-HT or noradrenergic function within bipolar I and bipolar II depressions. However, the finding of increased platelet 5-HT levels in bipolar depressed patients compared to normal controls is consistent with the results of previous studies, and may suggest an increase in presynaptic 5-HT reuptake, presumably resulting from diminished synaptic 5-HT availability in this condition.

Original languageEnglish
Pages (from-to)101-110
Number of pages10
JournalJournal of Affective Disorders
Volume52
Issue number1-3
DOIs
Publication statusPublished - 1999 Jan

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Psychiatry and Mental health

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