Platelet-activating factor-acetylhydrolase A379V (exon 11) gene polymorphism is an independent and functional risk factor for premature myocardial infarction

Ping-Yen Liu, Yi-Heng Li, Hua-Lin Wu, Ting-Hsing Chao, Liang-Miin Tsai, L. J. Lin, G. Y. Shi, Jyh Hong Chen

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Background: Oxidation of low density lipoproteins is an initial step of atherogenesis that generates pro-inflammatory phospholipids, including platelet-activating factor (PAF). PAF is degraded by PAF-acetylhydrolase (PAF-AH), which has been postulated to be a risk factor for myocardial infarction (MI). The role of PAF-AH for the onset of premature MI is unclear. Methods: Polymorphisms located in putatively functional regions were investigated in a cohort of patients having premature MI onset prior to 46 years of age (n = 200) and a sex-age-matched control group (n = 200). The activity of PAFAH and coronary angiograms were evaluated for the severity of coronary atherosclerosis. Results: The Vallele of A379V (e xon 11) polymorphism on PAF-AH gene was more frequent in patients with premature MI (P = 0.001). This V allele polymorphism was also associated with a lower activity of plasma PAF-AH and a more complex coronary atherosclerosis (p Trends < 0.05). Multiple logistic regression analysis showed that this polymorphism was an independent risk factor (Odds Ratio [OR] 1.66, 95% CI 1.14.1 to 5.80, P = 0.008) as well as smoking (OR 3.72, 95% CI 1.77 to 9.28, P = 0.001), diabetes mellitus (OR 2.25, 95% CI 1.40 to 5.32, P = 0.007) and hypertension (OR1.88, 95% CI 1.25 to 5.36, P = 0.003) for the onset of premature MI. Conclusion: We conclude that a functional and significant association between the A379V polymorphism on exon 11 of PAF-AH gene and premature MI exists in this Taiwanese population. This polymorphism is significantly associated with the PAF-AH activity and the severity of coronary atherosclerosis.

Original languageEnglish
Pages (from-to)1023-1028
Number of pages6
JournalJournal of Thrombosis and Haemostasis
Volume4
Issue number5
DOIs
Publication statusPublished - 2006 May 1

Fingerprint

Platelet Activating Factor
Exons
Myocardial Infarction
Genes
Coronary Artery Disease
Odds Ratio
LDL Lipoproteins
Phospholipids
Atherosclerosis
Diabetes Mellitus
Angiography
Research Design
Logistic Models
Smoking
Alleles
Regression Analysis
Hypertension
Control Groups
Population

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

@article{5ffdc03a7cb24eff804011fff63d51a8,
title = "Platelet-activating factor-acetylhydrolase A379V (exon 11) gene polymorphism is an independent and functional risk factor for premature myocardial infarction",
abstract = "Background: Oxidation of low density lipoproteins is an initial step of atherogenesis that generates pro-inflammatory phospholipids, including platelet-activating factor (PAF). PAF is degraded by PAF-acetylhydrolase (PAF-AH), which has been postulated to be a risk factor for myocardial infarction (MI). The role of PAF-AH for the onset of premature MI is unclear. Methods: Polymorphisms located in putatively functional regions were investigated in a cohort of patients having premature MI onset prior to 46 years of age (n = 200) and a sex-age-matched control group (n = 200). The activity of PAFAH and coronary angiograms were evaluated for the severity of coronary atherosclerosis. Results: The Vallele of A379V (e xon 11) polymorphism on PAF-AH gene was more frequent in patients with premature MI (P = 0.001). This V allele polymorphism was also associated with a lower activity of plasma PAF-AH and a more complex coronary atherosclerosis (p Trends < 0.05). Multiple logistic regression analysis showed that this polymorphism was an independent risk factor (Odds Ratio [OR] 1.66, 95{\%} CI 1.14.1 to 5.80, P = 0.008) as well as smoking (OR 3.72, 95{\%} CI 1.77 to 9.28, P = 0.001), diabetes mellitus (OR 2.25, 95{\%} CI 1.40 to 5.32, P = 0.007) and hypertension (OR1.88, 95{\%} CI 1.25 to 5.36, P = 0.003) for the onset of premature MI. Conclusion: We conclude that a functional and significant association between the A379V polymorphism on exon 11 of PAF-AH gene and premature MI exists in this Taiwanese population. This polymorphism is significantly associated with the PAF-AH activity and the severity of coronary atherosclerosis.",
author = "Ping-Yen Liu and Yi-Heng Li and Hua-Lin Wu and Ting-Hsing Chao and Liang-Miin Tsai and Lin, {L. J.} and Shi, {G. Y.} and Chen, {Jyh Hong}",
year = "2006",
month = "5",
day = "1",
doi = "10.1111/j.1538-7836.2006.01895.x",
language = "English",
volume = "4",
pages = "1023--1028",
journal = "Journal of Thrombosis and Haemostasis",
issn = "1538-7933",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Platelet-activating factor-acetylhydrolase A379V (exon 11) gene polymorphism is an independent and functional risk factor for premature myocardial infarction

AU - Liu, Ping-Yen

AU - Li, Yi-Heng

AU - Wu, Hua-Lin

AU - Chao, Ting-Hsing

AU - Tsai, Liang-Miin

AU - Lin, L. J.

AU - Shi, G. Y.

AU - Chen, Jyh Hong

PY - 2006/5/1

Y1 - 2006/5/1

N2 - Background: Oxidation of low density lipoproteins is an initial step of atherogenesis that generates pro-inflammatory phospholipids, including platelet-activating factor (PAF). PAF is degraded by PAF-acetylhydrolase (PAF-AH), which has been postulated to be a risk factor for myocardial infarction (MI). The role of PAF-AH for the onset of premature MI is unclear. Methods: Polymorphisms located in putatively functional regions were investigated in a cohort of patients having premature MI onset prior to 46 years of age (n = 200) and a sex-age-matched control group (n = 200). The activity of PAFAH and coronary angiograms were evaluated for the severity of coronary atherosclerosis. Results: The Vallele of A379V (e xon 11) polymorphism on PAF-AH gene was more frequent in patients with premature MI (P = 0.001). This V allele polymorphism was also associated with a lower activity of plasma PAF-AH and a more complex coronary atherosclerosis (p Trends < 0.05). Multiple logistic regression analysis showed that this polymorphism was an independent risk factor (Odds Ratio [OR] 1.66, 95% CI 1.14.1 to 5.80, P = 0.008) as well as smoking (OR 3.72, 95% CI 1.77 to 9.28, P = 0.001), diabetes mellitus (OR 2.25, 95% CI 1.40 to 5.32, P = 0.007) and hypertension (OR1.88, 95% CI 1.25 to 5.36, P = 0.003) for the onset of premature MI. Conclusion: We conclude that a functional and significant association between the A379V polymorphism on exon 11 of PAF-AH gene and premature MI exists in this Taiwanese population. This polymorphism is significantly associated with the PAF-AH activity and the severity of coronary atherosclerosis.

AB - Background: Oxidation of low density lipoproteins is an initial step of atherogenesis that generates pro-inflammatory phospholipids, including platelet-activating factor (PAF). PAF is degraded by PAF-acetylhydrolase (PAF-AH), which has been postulated to be a risk factor for myocardial infarction (MI). The role of PAF-AH for the onset of premature MI is unclear. Methods: Polymorphisms located in putatively functional regions were investigated in a cohort of patients having premature MI onset prior to 46 years of age (n = 200) and a sex-age-matched control group (n = 200). The activity of PAFAH and coronary angiograms were evaluated for the severity of coronary atherosclerosis. Results: The Vallele of A379V (e xon 11) polymorphism on PAF-AH gene was more frequent in patients with premature MI (P = 0.001). This V allele polymorphism was also associated with a lower activity of plasma PAF-AH and a more complex coronary atherosclerosis (p Trends < 0.05). Multiple logistic regression analysis showed that this polymorphism was an independent risk factor (Odds Ratio [OR] 1.66, 95% CI 1.14.1 to 5.80, P = 0.008) as well as smoking (OR 3.72, 95% CI 1.77 to 9.28, P = 0.001), diabetes mellitus (OR 2.25, 95% CI 1.40 to 5.32, P = 0.007) and hypertension (OR1.88, 95% CI 1.25 to 5.36, P = 0.003) for the onset of premature MI. Conclusion: We conclude that a functional and significant association between the A379V polymorphism on exon 11 of PAF-AH gene and premature MI exists in this Taiwanese population. This polymorphism is significantly associated with the PAF-AH activity and the severity of coronary atherosclerosis.

UR - http://www.scopus.com/inward/record.url?scp=33645650819&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645650819&partnerID=8YFLogxK

U2 - 10.1111/j.1538-7836.2006.01895.x

DO - 10.1111/j.1538-7836.2006.01895.x

M3 - Article

C2 - 16689754

AN - SCOPUS:33645650819

VL - 4

SP - 1023

EP - 1028

JO - Journal of Thrombosis and Haemostasis

JF - Journal of Thrombosis and Haemostasis

SN - 1538-7933

IS - 5

ER -