Platelet-activating factor-acetylhydrolase (PLA2G7) A379V (exon 11) gene polymorphism is functionally associated with coronary artery disease severity but not the onset of acute coronary syndrome

Ping Yen Liu, Hsing Chun Chung, Ju Yi Chen, Cheng Han Lee, Shih Hung Chan, Yi Heng Li, Li Jen Lin, Jyh Hong Chen

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background: Oxidation of low-density lipoproteins is an initial step of atherogenesis that generates proinflammatory phospholipids, including platelet-activating factor (PAF). PAF is degraded by PAF-acetylhydrolase (PAF-AH), which is also a risk factor for myocardial infarction. The role of PAF-AH in the onset of acute coronary syndrome (ACS) and its association with atherosclerosis among ACS patients are still unclear. Methods: PAF-AH encoding gene (PLA2G7) A379V variation was investigated in a cohort of patients having ACS (n = 200) and a sex-age-matched control group (n = 200). The activity of PAF-AH was evaluated by ELISA assay and coronary angiograms were evaluated among 100 ACS subjects for the severity of coronary atherosclerosis. Results: The V allele of A379V (exon 11) polymorphism on the PLA2G7 gene was more frequent in ACS patients (p = 0.02). This V allele polymorphism was also associated with a lower activity of plasma PAF-AH (VV vs. VA vs. AA: 9.8 ± 5.3 vs. 20.5 ± 7.7 vs. 24.8 ± 5.9 nmol/mL, respectively;p for trend = 0.03) and a more complex coronary atherosclerosis (diffuse score: VV vs. VA vs. AA: 7.3 ± 1.7 vs. 5.2 ± 1.4 vs. 3.4 ± 1.3, respectively;p for trend = 0.04). Multiple logistic regression analysis revealed three independent risk factors: smoking (OR 2.14, 95% CI 1.77 to 8.10, p = 0.02), diabetes mellitus (OR 2.08, 95% CI 1.55 to 5.32, p = 0.007) and hypertension (OR 3.18, 95% CI 1.15 to 7.36, p = 0.002), were all independent risk factors for the onset of ACS. However, this genetic variation did not show significant difference (OR 1.21, 95% CI 0.89 to 5.80, p = 0.18). Conclusion: We conclude that the PLA2G7/A379V polymorphism on exon 11 of PAF-AH gene is functionally associated with the PAF-AH activity and the severity of coronary atherosclerosis, but not onset of ACS, among Taiwanese population.

Original languageEnglish
Pages (from-to)212-220
Number of pages9
JournalActa Cardiologica Sinica
Volume22
Issue number4
Publication statusPublished - 2006 Dec

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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