Platelet compatibility improvement by proper choice of acidic terminal functionality for mixed-charge self-assembled monolayers

Ching Hsiung Shen, Jui-Che Lin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In this study two different series of mixed-charge self-assembled monolayers (SAMs) prepared with -N +(CH 3) 3-terminated alkanethiol and strong dissociated monovalent -SO 3H acid-terminated or weaker dissociated divalent -PO 3H 2 acid-terminated alkanethiol in pure ethanol were characterized. The influence of the acidity of the anionic functionality in the mixed-charge SAMs on the surface characteristics and platelet compatibility was investigated. X-ray photoelectron spectroscopy indicated that a nearly equivalent amount of countercharged terminal groups was noted on the surface of -SO 3H/-N +(CH 3) 3 mixed SAMs, while "-N +(CH 3) 3 thiol poor" phenomena were found on -PO 3H 2/-N +(CH 3) 3 mixed SAMs instead. This was caused by the distinct differences in solvation capability between the acidic anionic functional groups and solvent molecules and/or the interactions among the terminal ends of the thiols. This acidity difference also affected other interfacial properties and the platelet compatibility. The mixed SAMs formed from the mixture of -SO 3H- and -N +(CH 3) 3-terminated thiols showed higher surface hydrophilicity and exhibited the least amount of platelets adhered, but these two mixed SAMs were all fairly negatively surface charged. The structure of the hydration layer near the surfaces was likely affected by the acidity of the anionic functionality, and this would cause such a distinct behavior in platelet compatibility. It was concluded that the hydrophilic surfaces with nearly equal amounts of surface positively and negatively charged components could exhibit better platelet compatibility. This work demonstrated that the nature of the acidic terminal ends of alkanethiol is also a key factor for preparing mixed-charge SAMs with good platelet compatibility.

Original languageEnglish
Pages (from-to)640-647
Number of pages8
JournalLangmuir
Volume28
Issue number1
DOIs
Publication statusPublished - 2012 Jan 10

Fingerprint

Self assembled monolayers
Platelets
platelets
compatibility
methylidyne
Sulfhydryl Compounds
thiols
Acidity
acidity
acids
Acids
Solvation
Hydrophilicity
Hydration
Functional groups
solvation
hydration
Ethanol
ethyl alcohol
X ray photoelectron spectroscopy

All Science Journal Classification (ASJC) codes

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy

Cite this

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abstract = "In this study two different series of mixed-charge self-assembled monolayers (SAMs) prepared with -N +(CH 3) 3-terminated alkanethiol and strong dissociated monovalent -SO 3H acid-terminated or weaker dissociated divalent -PO 3H 2 acid-terminated alkanethiol in pure ethanol were characterized. The influence of the acidity of the anionic functionality in the mixed-charge SAMs on the surface characteristics and platelet compatibility was investigated. X-ray photoelectron spectroscopy indicated that a nearly equivalent amount of countercharged terminal groups was noted on the surface of -SO 3H/-N +(CH 3) 3 mixed SAMs, while {"}-N +(CH 3) 3 thiol poor{"} phenomena were found on -PO 3H 2/-N +(CH 3) 3 mixed SAMs instead. This was caused by the distinct differences in solvation capability between the acidic anionic functional groups and solvent molecules and/or the interactions among the terminal ends of the thiols. This acidity difference also affected other interfacial properties and the platelet compatibility. The mixed SAMs formed from the mixture of -SO 3H- and -N +(CH 3) 3-terminated thiols showed higher surface hydrophilicity and exhibited the least amount of platelets adhered, but these two mixed SAMs were all fairly negatively surface charged. The structure of the hydration layer near the surfaces was likely affected by the acidity of the anionic functionality, and this would cause such a distinct behavior in platelet compatibility. It was concluded that the hydrophilic surfaces with nearly equal amounts of surface positively and negatively charged components could exhibit better platelet compatibility. This work demonstrated that the nature of the acidic terminal ends of alkanethiol is also a key factor for preparing mixed-charge SAMs with good platelet compatibility.",
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Platelet compatibility improvement by proper choice of acidic terminal functionality for mixed-charge self-assembled monolayers. / Shen, Ching Hsiung; Lin, Jui-Che.

In: Langmuir, Vol. 28, No. 1, 10.01.2012, p. 640-647.

Research output: Contribution to journalArticle

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